Pseudonochelin (), a siderophore from a marine-derived sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was identified in . Annotation of a putative biosynthetic gene cluster combined with bioinformatics and isotopic enrichment studies enabled us to propose the biosynthesis of . Moreover, was found to display and antibacterial activity in an iron-dependent fashion.
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| http://dx.doi.org/10.1021/acs.orglett.2c01408 | DOI Listing |
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