Traditional monolithic fiber lasers can only achieve unidirectional high-power laser output. In this Letter, a novel high-power linear cavity fiber laser that can achieve bidirectional high-power output is proposed and demonstrated. In an ordinary laser resonant cavity, we replace the high-reflectivity fiber Bragg grating with a low-reflectivity fiber Bragg grating to realize bidirectional laser output. In our experiment, the laser cavity was composed of two fiber Bragg gratings with a reflectivity of about 10%. The pump power provided by the 976 nm laser diodes was injected into a double-clad Yb-doped fiber with core/cladding diameters of 20/400 µm. At the maximum pump power, the bidirectional output powers were 2025 W and 1948 W, respectively, and the output laser beam quality (M factor) at both ends was about 1.5. For the first time, to the best of our knowledge, the feasibility of a bidirectional output fiber laser that can achieve double high (2-kW-level) power was verified. Compared with a traditional unidirectional output laser, this type of bidirectional output laser can achieve a double high-power laser by employing a laser resonant cavity. Thus, the average cost and structure size can be further reduced in mass production.
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http://dx.doi.org/10.1364/OL.458581 | DOI Listing |
ACS Appl Mater Interfaces
January 2025
Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, The Tenth Affiliated Hospital (Dongguan People's Hospital), Southern Medical University, Dongguan, Guangdong 523058, China.
Ferroptosis combined with photodynamic therapy (PDT) has emerged as a powerful approach to induce cancer cell death by producing and accumulating lethal reactive oxygen species (ROS) in the tumor microenvironment (TME). Despite its efficacy and safety, challenges persist in delivering multiple drugs to the tumor site for enhanced antitumor efficacy and improved tissue targeting. Hence, we designed a method of inducing ferroptosis through laser-mediated and human homologation-specific efficient activation, which is also a ferroptosis therapy with higher safety through ROS-mediated.
View Article and Find Full Text PDFPhotodiagnosis Photodyn Ther
January 2025
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:
Background: Candida albicans is the primary cause of vulvovaginal candidiasis, a worldwide health concern for women. The use of supplemental methods, such as antimicrobial photodynamic therapy (aPDT) and probiotics, was promoted by the ineffectiveness of the existing antifungal drugs.
Methods: This study examines the combined effects of probiotics (Bacillus and Enterococcus isolated from the fermented pickles) and PDT (using red laser (655 nm, 18 J/cm) as a light source and methylene blue dye (30 mg/mL) as a photosensitizer) on the in vitro virulence activity of C.
Photodiagnosis Photodyn Ther
January 2025
Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong. Electronic address:
Arch Biochem Biophys
January 2025
Department of Pain Management, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address:
Yes-associated protein (YAP), a focal point of current biological research, is involved in regulating various life processes. In this report, live-cell fluorescence resonance energy transfer (FRET) imaging was employed to unravel the YAP complexes in MCF-7 cells. Fluorescence imaging of living cells co-expressing CFP (cyan fluorescent protein)-YAP and YFP (yellow fluorescent protein)-LATS1 (large tumor suppressor 1) plasmids revealed that YAP promoted LATS1 oligomerization around mitochondria.
View Article and Find Full Text PDFPhytomedicine
January 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China,; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China, ; The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.
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