We describe a catalytic strategy for direct single C(sp)-F bond alkylation of trifluoromethylbenzimidazoles under a photoinduced thiol catalysis process. The CO radical anion (CO) proved to be the most efficient single-electron reductant to realize such a transformation. The spin-center shift of the generated radical anion intermediate is the key step in realizing C-F bond activation under mild conditions with high efficiency.
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| http://dx.doi.org/10.1021/acs.orglett.2c01533 | DOI Listing |
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