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Autoencoder based data clustering for identifying anomalous repetitive hand movements, and behavioral transition patterns in children.
Phys Eng Sci Med
January 2025
Institute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Applied Sciences and Arts of Southern Switzerland, Via Pobiette, Manno, 6928, Manno, Switzerland.
The analysis of repetitive hand movements and behavioral transition patterns holds particular significance in detecting atypical behaviors in early child development. Early recognition of these behaviors holds immense promise for timely interventions, which can profoundly impact a child's well-being and future prospects. However, the scarcity of specialized medical professionals and limited facilities has made detecting these behaviors and unique patterns challenging using traditional manual methods.
View Article and Find Full Text PDFChild routines across preschool and associations with socioemotional adjustment.
J Fam Psychol
January 2025
Department of Human Development and Family Studies, University of Wisconsin-Madison.
Although a large body of research has documented the importance of routines for children's development, the role of developmental timing of routines has received less attention. The present study examined how use of routines across the preschool period is linked to children's socioemotional adjustment. We used Year 3 and Year 5 data from the Future of Families and Child Wellbeing Study ( = 2,353; 48% female).
View Article and Find Full Text PDFComparison of clinical artificial oocyte activation protocols on mouse egg activation and embryo development.
Reproduction
January 2025
D Cohen, Fundación IBYME. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)., Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
Artificial oocyte activation (AOA) with Ca2+ ionophores is an experimental procedure that benefits patients who fail to obtain fertilized eggs. However, the impact of non-physiological Ca2+ increases on cellular events involved in egg-embryo transition and early development remains poorly understood. Using the mouse model, this study compares common Ca2+ ionophore protocols applied in clinical practice - one or two exposures to A23187 or a single exposure to ionomycin - focusing on embryonic development and cellular events associated with egg activation.
View Article and Find Full Text PDFMultimodal multiobjective optimization with structural network control principles to optimize personalized drug targets for drug discovery of individual patients.
Brief Bioinform
November 2024
School of Electrical and Information Engineering, Zhengzhou University, No. 100, Science Avenue, Hightech District, Zhengzhou City 450001, Henan Province, China.
Structural network control principles provided novel and efficient clues for the optimization of personalized drug targets (PDTs) related to state transitions of individual patients. However, most existing methods focus on one subnetwork or module as drug targets through the identification of the minimal set of driver nodes and ignore the state transition capabilities of other modules with different configurations of drug targets [i.e.
View Article and Find Full Text PDFAn EEG-based framework for automated discrimination of conversion to Alzheimer's disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study.
Front Aging Neurosci
January 2025
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Background: As a clinical precursor to Alzheimer's disease (AD), amnestic mild cognitive impairment (aMCI) bears a considerably heightened risk of transitioning to AD compared to cognitively normal elders. Early prediction of whether aMCI will progress to AD is of paramount importance, as it can provide pivotal guidance for subsequent clinical interventions in an early and effective manner.
Methods: A total of 107 aMCI cases were enrolled and their electroencephalogram (EEG) data were collected at the time of the initial diagnosis.
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