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http://dx.doi.org/10.1016/j.jdcr.2022.02.043 | DOI Listing |
JAAD Case Rep
June 2022
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.
Am J Dermatopathol
June 2015
*Department of Pathology, Divisions of Dermatology and Dermatopathology, Albany Medical College, Albany, NY; †Upper Hudson Valley Dermatology, Castleton, NY; and ‡Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.
The Jarisch-Herxheimer reaction (JHR) is a transient inflammatory syndrome triggered hours after the start of antibiotic treatment of spirochete infections, namely syphilis. Clinically, JHR manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. JHR's pathogenesis is unclear and it is histopathologically rarely reported.
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