AI Article Synopsis
- Cancer is a challenging disease with few effective treatments, but cold atmospheric plasma (CAP) shows promise by selectively targeting and killing tumor cells.
- A narrative review was conducted to explore CAP's therapeutic effects on solid tumors, including its interaction with tumor microenvironment, immune responses, and cellular mechanisms.
- The review highlights CAP's dose-dependent effects, suggesting that optimal doses can kill tumor cells and influence the surrounding non-malignant cells and extracellular matrix, while also providing guidance for future research efforts.
Article Abstract
Cancer is a devastating disease, and there is no particularly effective treatment at present. Recently, a new treatment, cold atmospheric plasma (CAP), has been proposed. At present, CAP is confirmed to have selective killing effect on tumor by many studies and . A targeted literature search was carried out on the study of cold atmospheric plasma. Through analysis and screening, a narrative review approach was selected to describe therapeutic effects of cold atmospheric plasma on solid tumor. According to the recent studies on plasma, some hypothetical therapeutic schemes of CAP are proposed in this paper. The killing mechanism of CAP on solid tumor is expounded in terms of the selectivity of CAP to tumor, the effects of CAP on cells, tumor microenvironment (TME) and immune system. CAP has many effects on solid tumors, and these effects are dose-dependent. The effects of optimal doses of CAP on solid tumors include killing tumor cells, inhibiting non-malignant cells and ECM in TME, affecting the communication between tumor cells, and inducing immunogenic death of tumor cells. In addition, several promising research directions of CAP are proposed in this review, which provide guidance for future research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9139675 | PMC |
| http://dx.doi.org/10.3389/fmed.2022.884887 | DOI Listing |
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