Tildrakizumab: Successful Response in Two Patients With Psoriatic Arthritis.

Dermatol Pract Concept

Dermatology Unit, Department of Mentals and Physical Health and Preventive medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

Published: May 2022

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116554PMC
http://dx.doi.org/10.5826/dpc.1202a49DOI Listing

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Article Synopsis
  • The management of pediatric dermatological conditions has advanced with new biologics and small molecule therapies, originally approved for adults but now being evaluated for children and adolescents.
  • The review aims to summarize recently FDA-approved and potential therapies for conditions like alopecia areata, psoriasis, atopic dermatitis, and hidradenitis suppurativa in pediatric patients.
  • Key findings include FDA-approved treatments such as ritlecitinib for alopecia areata and multiple biologics for pediatric psoriasis and atopic dermatitis, with several others undergoing phase 3 clinical trials for potential approval.
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Acrodermatitis continua of Hallopeau is a rare, localized variant of pustular psoriasis commonly associated with join disease and severe quality of life impairment. While there are no standard treatment guidelines, therapies used for psoriasis vulgaris are commonly tried. We report a case of severe acrodermatitis continua of Hallopeau in a patient with multiple comorbidities (advanced malignancy, recurrent empyema, psoriatic arthritis) where tildrakizumab lead to a rapid resolution of skin and joint disease which was maintained 1 year later.

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Advances in treatment with biological agents have changed the course of psoriasis. However observational reports and controlled trials draw attention to the heterogeneity of treatment response and point out that Body Mass index (BMI) may be a key factor for therapy efficacy. Therefore, we investigated the impact of BMI on the efficacy of the most recent biological molecules (anti IL-23 inhibitors) to improve patient care management.

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