This study investigates the mechanical response of antibacterial PA12/TiO nanocomposite 3D printed specimens by varying the TiO loading in the filament, raster deposition angle, and nozzle temperature. The prediction of the antibacterial and mechanical performance of such nanocomposites is a challenging field, especially nowadays with the covid-19 pandemic dilemma. The experimental work in this study utilizes a fully factorial design approach to analyze the effect of three parameters on the mechanical response of 3D printed components. Therefore, all combinations of these three parameters were tested, resulting in twenty-seven independent experiments, in which each combination was repeated three times (a total of eighty-one experiments). The antibacterial performance of the fabricated PA12/TiO nanocomposite materials was confirmed, and regression and arithmetic artificial neural network (ANN) models were developed and validated for mechanical response prediction. The analysis of the results showed that an increase in the TiO% loading decreased the mechanical responses but increased the antibacterial performance of the nanocomposites. In addition, higher nozzle temperatures and zero deposition angles optimize the mechanical performance of all TiO% nanocomposites. Independent experiments evaluated the proposed models with mean absolute percentage errors (MAPE) similar to the ANN models. These findings and the interaction charts show a strong interaction between the studied parameters. Therefore, the authors propose the improvement of predictions by utilizing artificial neural network models and genetic algorithms as future work and the spreading of the experimental area with extra variable parameters and levels.
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http://dx.doi.org/10.1007/s00170-022-09376-w | DOI Listing |
Ultrasound Med Biol
January 2025
Institute of Biomedical Technologies, Auckland University of Technology, Auckland City, 1010, Auckland, New Zealand. Electronic address:
Objective: This study aims to evaluate the viability of a hypothesis for selective targeting of skin cancer cells by exploiting the spectral gap with healthy cells using analytical and numerical simulation.
Methods: The spectral gap was first identified using a viscoelastic dynamic model, with the physical and mechanical properties of healthy and cancerous skin cells deduced from previous experimental studies conducted on cell lines. The outcome of the analytical simulation was verified numerically using modal and harmonic analysis.
Matrix Biol
January 2025
Department of Surgery, Emory University, Atlanta, GA, USA; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Research Services, Atlanta VA Medical Center, Decatur, GA, USA. Electronic address:
Arterial endothelial cells (ECs) reside in a complex biomechanical environment. ECs sense and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of disturbed flow and commonly found at arterial bifurcations and around atherosclerotic plaques.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Department of Molecular Medicine, Centro de Investigaciones Biológicas Margarita Salas (CIB Margarita Salas-CSIC), Madrid, Spain. Electronic address:
Epigenetic alterations are hallmarks of cancer, with histone modifiers playing critical roles in gene transcription, DNA homeostasis, and other nuclear functions. Lysine-specific demethylase 1 (LSD1), a key regulator of H3K4 methylation, has emerged as a promising pharmacological target in cancer treatment, including leukemia. Acute lymphoblastic leukemia (ALL), the most common pediatric cancer, remains a significant therapeutic challenge due to limited understanding of how epigenetic therapy impacts leukemia dissemination.
View Article and Find Full Text PDFBiomed Pharmacother
January 2025
Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Neurochemistry, 12 Smetna Str., Krakow 31-343, Poland. Electronic address:
Neuropathic pain is a disorder affecting the somatosensory nervous system. However, this condition is also characterized by significant neuroinflammation, primarily involving CNS-resident non-neuronal cells. A promising target for developing new analgesics is histamine H receptor (HR); thus, we aimed to determine the influence of a novel HR antagonist/inverse agonist, E-98 (1-(7-(4-chlorophenoxy)heptyl)-3-methylpiperidine), on pain symptoms and glia activation in model of neuropathic pain in male mice (chronic constriction injury to the sciatic nerve).
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Department of Mechanical, Robotics and Energy Engineering, Dongguk University, Seoul 04620, Republic of Korea. Electronic address:
This paper introduces a highly absorbent and sensitive cellulose nanofiber (CNF)/gold nanorod (GNR)@Ag surface-enhanced Raman scattering (SERS) sensor, fabricated using the vacuum filtration method. By optimizing the Ag thickness in the GNR@Ag core-shell structures and integrating them with CNFs, optimal SERS hotspots were identified using the Raman probe molecule 4-aminothiophenol (4-ATP). To concentrate pesticides extracted from fruit and vegetable surfaces, we utilized the evaporation enrichment effect using hydrophilic CNF and hole-punched hydrophobic polydimethylsiloxane (PDMS).
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