Over the past several decades, the study of Spitz neoplasms has flourished, with expanded conceptualization and refined terminology, providing a framework for the assessment and classification of Spitz nevi, atypical Spitz Tumors, and Spitz melanoma. Cancer genomics have generated concepts such as driver and passenger genes and clonal evolution, which can be applied to Spitz tumors. Herein, we provide a historical perspective, followed by a summary of current knowledge and clinical approaches for these challenging tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149815 | PMC |
| http://dx.doi.org/10.3390/dermatopathology9020017 | DOI Listing |
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- Spitz nevus is a rare benign tumor and this study examined its characteristics among Iranian patients from 2016-2021, focusing on demographics and histopathology.
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Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
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- The Spitz group of melanocytic tumors should ideally include those with specific genomic changes like kinase receptor fusions and HRAS mutations, while traditional melanoma markers like BRAF mutations indicate a different diagnosis.
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