[Epidemiological and etiological analysis of two infantile cases of serogroup B epidemic cerebrospinal meningitis epidemics in Shandong Province, 2021].

Zhonghua Yu Fang Yi Xue Za Zhi

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention/Shandong Academy of Preventive Medicine; Academy of Preventive Medicine, Shandong University/Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

Published: May 2022

Two cases of epidemic situation of serogroup B meningitis in infants in Shandong Province in 2021 were investigated. Samples of cases and their close contacts were collected for isolation, culture and identification of (). The isolates were subjected to multi-locus sequence typing, outer membrane protein and genotyping and drug sensitivity test. Two laboratory-confirmed outbreaks of serogroup B meningitis were reported from Yantai city and Linyi city. The indicated cases were infants aged 5 months and 2 months old respectively. They were not vaccinated with meningitis vaccine. Their epidemiological characteristics and clinical manifestations were similar and the prognosis was good. The same sequence type (ST) of serogroup B strains as the indicated cases was detected in the samples of close family contacts, but without subsequent cases. Among them, Yantai strain was were identified as the type ST-8920, belonging to CC4821 clonal complex, and the genotypes of and were p1.21-2, 23 and F3-1. Linyi strain was a new type, belonging to CC4821 clonal complex and the genotypes of and were p1.20, 23 and F1-91. The above strains were resistant to penicillin, ciprofloxacin, levofloxacin and Chemitrim, and their sensitivity to cephalosporin decreased. Two cases of infant serogroup B epidemic were relatively rare in China, which were different from the epidemiological and pathogenic characteristics of other serogroups in the past.

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Source
http://dx.doi.org/10.3760/cma.j.cn112150-20210729-00727DOI Listing

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