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Background: North Carolina (NC) House Bill 96, effective February 2022, enabled trained immunizing pharmacists across the state to prescribe hormonal contraceptives (HCs). However, the extent and barriers to deployment are unknown. The purpose of this study was to describe the uptake and challenges from outpatient pharmacists who trained to provide HCs in an outpatient practice to assist others in the implementation of this service.
View Article and Find Full Text PDFBilateral evolution of OCT biomarkers in dry AMD: Long-term follow up study.
Eur J Ophthalmol
May 2024
UPMC Eye Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Purpose: To report the emergence and progress of four late-stage characteristics: incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA), drusen ooze and drusen collapse in eyes with dry age-related macular degeneration (AMD) using Spectral Domain Optical Coherence Tomography (SD-OCT).
Methods: This was a retrospective analysis of eyes with non-exudative AMD. Multimodal imaging was done at follow up visits ≤ 12 months.
Reprint of: Incomplete Brown-Séquard syndrome following cervical stab wound.
Dis Mon
September 2022
Emergency Medicine Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature
May 2021
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere loss that is caused by incomplete genome end replication. In humans, telomerase is upregulated during embryogenesis and in cancers, and mutations that compromise the function of telomerase result in disease. A previous structure of human telomerase at a resolution of 8 Å revealed a vertebrate-specific composition and architecture, comprising a catalytic core that is flexibly tethered to an H and ACA (hereafter, H/ACA) box ribonucleoprotein (RNP) lobe by telomerase RNA.
View Article and Find Full Text PDFReprint of: Thoracolumbar burst fractures associated with incomplete neurological deficit in patients under the age of 40: Is the posterior approach enough? Surgical treatment and results in a case series of 10 patients with a minimum follow-up of 2 years.
Injury
August 2020
Division of Spine Surgery, Department of Orthopaedics and Traumatology, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy. Electronic address:
Introduction: Surgical management of thoracolumbar burst fractures is controversial. While the goals of surgical treatment are well accepted (i.e.
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