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Activatable Photosensitizer Prodrug for Self-Amplified Immune Therapy via Pyroptosis.
Angew Chem Int Ed Engl
January 2025
Hunan University, College of Chemistry and Chemical Engineering, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistr, 410082, Changsha, CHINA.
Immunotherapy is a promising cancer treatment, but its application is hindered by tumors' low immunogenicity and the difficulty of immune cell infiltration. Here, to address above issues and achieve targeted tumor treatment, we designed the first activated small molecule photosensitizer immune-prodrug HDIM based on pyroptosis, and proposed a self-amplified immune therapy strategy (SITS) for enhanced tumor therapy. HDIMcan be specifically activated by the tumor hypoxiaand then simultaneously initiate immuno-therapy and photodynamic therapy (PDT)-induced pyroptosis with NIR laser irradiation.
View Article and Find Full Text PDFBaseline Participant Characteristics are Associated With Engagement in a Movement-Based RCT for Chronic Low-Back Pain.
Am J Health Promot
January 2025
Ikerbasque Research Foundation and Department of Clinical, Health Psychology, and Research Methods, School of Psychology, University of the Basque Country, UPV/EHU, Leioa, Spain.
Purpose: Examine whether baseline participant characteristics predict engagement in a movement-based RCT for chronic low back pain (CLBP).
Design: Longitudinal study within an RCT.
Setting: Online.
Impact of luteal blood perfusion and expression of estrus on pregnancy rates of Bos taurus embryo recipients exposed to fixed-time embryo transfer.
Anim Reprod Sci
January 2025
University of Georgia, Department of Animal and Dairy Sciences, Athens, GA 30602, USA. Electronic address:
This study evaluated the impact of luteal blood perfusion (BP) and expression of estrus on pregnancy rates of Bos taurus embryo recipients exposed to fixed-timed embryo transfer (FTET) using a gonadotropin-releasing hormone (GnRH)- and progesterone-based ovulation synchronization protocol. Postpartum beef cows (n = 746) were exposed to a GnRH/progesterone-based ovulation synchronization protocol. Luteal morphometry and BP were assessed using color Doppler ultrasonography 9 days after CIDR removal concurrently with FTET.
View Article and Find Full Text PDFQuantitative analysis of particle behavior constituting multiple coherent structures in liquid bridges.
J Colloid Interface Sci
January 2025
Department of Mechanical and Aerospace Engineering, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan. Electronic address:
Hypothesis: Coherent structures by low-Stokes-number particles are induced within a closed flow, in which ordered flow regions known as Kolmogorov-Arnold-Moser (KAM) tori emerge. A variety of structures with different spatial characteristics has been predicted by varying the Stokes number, whereas the coexistence of structures in flow suspending various types of particles has not been hitherto demonstrated.
Experiments: Half-zone liquid bridges of O () are prepared as a closed system to induce thermocapillary-driven time-dependent flow under normal gravity conditions.
Oral Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis.
ACS Appl Mater Interfaces
January 2025
Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered by low drug accumulation and retention in colonic lesions. Inspired by intestine colonizing bacterium, we developed a mucoadhesive probiotic -mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) for UC-targeted therapy via repairing intestinal barrier and scavenging RONS.
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