MicroRNAs (miRNAs) are small non-coding RNAs that participate in various biological and cellular processes by regulating target gene expression. miRNAs are also known to play vital roles in the pathogenesis of various diseases, including infections, as well as the disease progression and defense responses. In this study, we examined the expression levels of pol-miR-140-3p and its target gene, kinesin family member 5A (KIF5A), in association with the Streptococcus parauberis (S. parauberis) infection, a major bacterial pathogen that causes streptococcosis in olive flounder (Paralichthys olivaceus). KIF5A is a heavy chain isoform of kinesin-1, which is known to be brain-specific, and this study is the first examination of KIF5A expression related to the regulation of miRNA in olive flounder (named PoKIF5A). There were significant differences in expression levels between infected and healthy olive flounder as the expression of pol-miR-140-3p in the infected fish was lower than that in the control, while the expression of PoKIF5A was higher in the infected fish than in the healthy controls. These contradictory results suggest that downregulated pol-miR-140-3p induces the expression of PoKIF5A against S. parauberis infection in olive flounder.
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http://dx.doi.org/10.1016/j.fsi.2022.05.043 | DOI Listing |
Sci Data
December 2024
Department of Convergent Bioscience and Informatics, Chungnam National University, Daejeon, 34134, Korea.
Animals (Basel)
November 2024
Department of Marine Biology and Aquaculture, College of Marine Science, Gyeongsang National University, Tongyeong 53064, Gyeongsangnam-do, Republic of Korea.
Emaciation disease has directly affected the production of olive flounder-a major aquaculture species in Korea-since the 2000s. Various myxosporeans have been reported as its causative agents. In this study, we investigated the recent resurgence of emaciation on Jeju Island, considering not only myxosporean infections but also potential environmental factors.
View Article and Find Full Text PDFFish Shellfish Immunol
January 2025
College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Yuseong-gu, Daejeon 34134, Republic of Korea. Electronic address:
Aquac Nutr
July 2024
Department of Marine Life Sciences Jeju National University, Jeju 63243, Republic of Korea.
This study was conducted to estimate dietary valine (Val) requirement for juvenile olive flounder (). In a feeding trial, a total of 540 fish (initial body weight: 23.0 ± 0.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Food Science and Biotechnology, College of Engineering, Ewha Womans University, Seoul, 03760, South Korea.
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