DNA/RNA duplexes containing metal-ion-mediated base pairs (metallo-base pairs) have potential applications in developing nucleic acid-based nanodevices and genetic code expansion. Many metallo-base pairs are formed within duplexes stabilized by Watson-Crick base pairs. Recently, the crystal structure of an Ag -DNA nanowire with an uninterrupted one-dimensional silver array was determined. Here, we present a new DNA helical wire, the "Ag -DNA rod", containing an uninterrupted array of 11 Ag ions. The Ag -DNA rod consisted of only C-Ag -C, G-Ag -G, G-Ag -5-bromouracil ( U), and U-Ag - U metallo base pairs, with no Watson-Crick pairs. The Ag -DNA rods were connected by non-canonical G-G pairs in crystals. Notably, data from our absorbance, circular dichroism, nuclear magnetic resonance, and mass spectrometry analyses suggested that the Ag -DNA rods formed in solution, as well as within crystals.
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