To examine how sociodemographic characteristics and non-pharmaceutical interventions affect the transmission of COVID-19, we analyze patient profiles and contact tracing data from almost all cases in an outbreak in Shijiazhuang, China, from January to February 2021. Because of universal testing and digital tracing, the data are of high quality. Results from negative binomial models indicate that the counts of close contacts and secondary infections vary with the cases' age and occupation. Notably, cases under age 18 are causing an increased infection rate among their close contacts and leading to more within-neighborhood secondary infections than adults aged 18-49. Also, county-wide interventions and lockdown are found to be effective at containing the spread of COVID-19. These measures can reduce the number of close contacts that each case has and largely restrict the remaining infections to the case's neighborhood. These results suggest that transmission risks of COVID-19 are associated with the case's sociodemographic characteristics and can be reduced with interventions at the county level. Implications on mitigation measures and reopening plans are discussed.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154201 | PMC |
http://dx.doi.org/10.1007/s11524-022-00639-1 | DOI Listing |
BMC Med Res Methodol
January 2025
United Kingdom Health Security Agency (UKHSA), London, UK.
Background: SIREN is a healthcare worker cohort study aiming to determine COVID-19 incidence, duration of immunity and vaccine effectiveness across 135 NHS organisations in four UK nations. Conducting an intensive prospective cohort study during a pandemic was challenging. We designed an evolving retention programme, informed by emerging evidence on best practice.
View Article and Find Full Text PDFGeroscience
January 2025
Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Research in aging often refers to animal models, particularly C57BL/6J (B6J) mice, considered gold standard. However, B6J mice are distributed by different suppliers, which results in divers substrains exhibiting notable phenotypic differences. To ensure a suitable phenotype of cardiac aging, we performed heart analyses of young (5 months) and old B6J mice (24 months) from two substrains: B6JRj (Janvier) and B6JCrl mice (Charles River).
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
This introductory chapter traces the evolution of (bio)chemical assays, emphasizing the critical role of robust protocols in ensuring reproducibility-a fundamental aspect of scientific research. With the advent of systems biology, the need for standardized methods has intensified, particularly for integrating vast datasets in open-access formats. The historical progression from basic plant morphology to advanced chromatographic and spectroscopic techniques in phytochemistry highlights the necessity for precise, reproducible protocols.
View Article and Find Full Text PDFJ Neural Transm (Vienna)
January 2025
Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, Essen University Medical School, University of Duisburg-Essen, 45147, Essen, Germany.
Attention-deficit/hyperactivity disorder (ADHD) is a frequently observed condition, with about 70% of individuals diagnosed with ADHD experiencing irregular sleep-wake patterns. Beyond the primary symptoms of ADHD, there is a significant overlap with sleep-related issues, indicating that disrupted sleep patterns may exacerbate ADHD symptoms. ADHD-related sleep problems can be traced to a delayed circadian rhythm and a later onset of melatonin production.
View Article and Find Full Text PDFMol Metab
January 2025
Peking-Tsinghua Center for Life Sciences, Beijing, China 100871; PKU-IDG/McGovern Institute for Brain Research, Beijing, China 100871; School of Psychological and Cognitive Sciences, Peking University, Beijing, China 100871; Beijing Key Laboratory of Behavior and Mental Health, Beijing, China 100871; Biosciences and Nutrition Unit, Department of Medicine Huddinge, Karolinska Institute, Huddinge, Sweden 14183. Electronic address:
The capacity of mature adipocytes to de-differentiate into fibroblast-like cells has been demonstrated in vitro and a few, rather specific in vivo conditions. A detailed comparison between de-differentiated fat (DFAT) cells and adipose stem and progenitor cells (ASPCs) from different adipose depots is yet to be conducted. Moreover, whether de-differentiation of mature adipocytes from classical subcutaneous and visceral depots occurs under physiological conditions remains unknown.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!