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Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives. | LitMetric

Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives.

Angew Chem Int Ed Engl

Department of Emergency, State Key Laboratory of Biotherapy, West China Hospital, and School of Chemical Engineering, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.

Published: August 2022

AI Article Synopsis

  • The study presents the use of common alkyl sulfoxides as radical precursors for creating various pyridine derivatives through a light-activated process.* -
  • The reaction involves the formation of electron donor-acceptor (EDA) complexes in solution, effectively broadening the application scope for both sulfoxides and N-methoxy pyridinium salts.* -
  • Glycosyl sulfoxides can be transformed into pyridyl C-glycosides with high selectivity, and both computational and experimental research shed light on the underlying reaction mechanisms.*

Article Abstract

We report here the use of simple and readily available alkyl sulfoxides as precursors to radicals and their application in the preparation of pyridine derivatives. We show that alkyl sulfoxides, N-methoxy pyridinium salts and fluoride anions form electron donor-acceptor (EDA) complexes in solution, which, upon visible light irradiation, undergo a radical chain process to afford various pyridine derivatives smoothly. This reaction displays broad scope with respect to both sulfoxides and N-methoxy pyridiniums. The synthetic versatility of sulfoxides as a handle in chemistry adds to their power as radical precursors. Glycosyl sulfoxides are converted to the corresponding pyridyl C-glycosides with high stereoselectivities. Computational and experimental studies provide insights into the reaction mechanism.

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Source
http://dx.doi.org/10.1002/anie.202204922DOI Listing

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