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FUNAGE-Pro: comprehensive web server for gene set enrichment analysis of prokaryotes. | LitMetric

FUNAGE-Pro: comprehensive web server for gene set enrichment analysis of prokaryotes.

Nucleic Acids Res

Department of Molecular Genetics, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute, the Netherlands.

Published: July 2022

AI Article Synopsis

Article Abstract

Recent advances in the field of high throughput (meta-)transcriptomics and proteomics call for easy and rapid methods enabling to explore not only single genes or proteins but also extended biological systems. Gene set enrichment analysis is commonly used to find relations in a set of genes and helps to uncover the biological meaning in results derived from high-throughput data. The basis for gene set enrichment analysis is a solid functional classification of genes. Here, we describe a comprehensive database containing multiple functional classifications of genes of all (>55 000) publicly available complete bacterial genomes. In addition to the most common functional classes such as COG and GO, also KEGG, InterPro, PFAM, eggnog and operon classes are supported. As classification data for features is often not available, we offer fast annotation and classification of proteins in any newly sequenced bacterial genome. The web server FUNAGE-Pro enables fast functional analysis on single gene sets, multiple experiments, time series data, clusters, and gene network modules for any prokaryote species or strain. FUNAGE-Pro is freely available at http://funagepro.molgenrug.nl.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252808PMC
http://dx.doi.org/10.1093/nar/gkac441DOI Listing

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