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Reactive oxygen species: Orchestrating the delicate dance of platelet life and death.
Redox Biol
January 2025
School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China. Electronic address:
Article Synopsis
- Platelets play a critical role in blood clotting and the immune response, relying on a balanced relationship between their production and destruction influenced by reactive oxygen species (ROS).
- Moderate levels of ROS enhance platelet production and function, aiding in processes like collagen binding and thrombus formation, but high levels can lead to platelet apoptosis and increased risk of thrombosis.
- The review emphasizes the need for further research into specific ROS signaling pathways, which could lead to new therapies for platelet-related disorders by leveraging the beneficial aspects of ROS while managing their harmful effects.
Protocol for measuring the effects of an inhibitory signal associated with danger on honey bee dopamine levels.
STAR Protoc
September 2024
Division of Biological Sciences, Section of Ecology, Behavior, and Evolution, University of California San Diego, La Jolla, CA 92093, USA. Electronic address:
Article Synopsis
- The stop signal in honey bees is triggered by negative experiences at food sources and prevents them from performing waggle dances.
- The protocol outlines how to measure the impact of danger signals on dopamine levels in honey bees through methods like observing colonies and simulating hornet attacks.
- It includes detailed instructions for recording bee behaviors and measuring brain dopamine levels under varying conditions, with additional information available in the cited study by Dong et al.
Dancing with danger-how honeybees are getting affected in the web of microplastics-a review.
NanoImpact
July 2024
Department of Agricultural Economics, Lovely Professional University, Phagwara, Punjab, India, 144411.
Anthropogenic activities have negatively impacted the ecosystem dramatically over the last few decades. The environment is becoming more contaminated with heavy metals, pesticides, and microplastics (MPs) as a result of the swift rise in industrialization and urbanisation. These contaminants are present everywhere in the ecosystem, affecting every living creature, from aquatic to terrestrial to aerial.
View Article and Find Full Text PDFThe dangerous "West Coast Swing" by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism.
Pharmacol Res
March 2024
Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Growing epidemiological studies highlight a bi-directional relationship between depressive symptoms and diabetes mellitus. However, the detrimental impact of their co-existence on mental health suggests the need to treat this comorbidity as a separate entity rather than the two different pathologies. Herein, we characterized the peculiar mechanisms activated in mouse hippocampus from the concurrent development of hyperglycaemia, characterizing the different diabetes subtypes, and chronic stress, recognized as a possible factor predisposing to major depression.
View Article and Find Full Text PDFNocturnal selective pressures on the evolution of human musicality as a missing piece of the adaptationist puzzle.
Front Psychol
October 2023
Department of Experimental Psychology, Institute of Psychology, University of São Paulo, São Paulo, Brazil.
Human musicality exhibits the necessary hallmarks for biological adaptations. Evolutionary explanations focus on recurrent adaptive problems that human musicality possibly solved in ancestral environments, such as mate selection and competition, social bonding/cohesion and social grooming, perceptual and motor skill development, conflict reduction, safe time-passing, transgenerational communication, mood regulation and synchronization, and credible signaling of coalition and territorial/predator defense. Although not mutually exclusive, these different hypotheses are still not conceptually integrated nor clearly derived from independent principles.
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