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| http://dx.doi.org/10.1016/j.cca.2022.05.019 | DOI Listing |
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The never ending story of Hb-variants interferences on the measurement of HbA1c.
Clin Chim Acta
July 2022
University of East Anglia, Faculty of Medicine and Health, Norwich Research Park, NR4 7TJ, United Kingdom; Norfolk and Norwich University Hospital, Department of Clinical Biochemistry, Norwich, UK.
Are hemoglobin A point-of-care analyzers fit for purpose? The story continues.
Clin Chem Lab Med
March 2021
University of East Anglia, Faculty of Medicine and Health, Norwich Research Park, Norwich, UK.
Objectives: Point-of-care (POC) analyzers are playing an increasingly important role in diabetes management but it is essential that we know the performance of these analyzers in order to make appropriate clinical decisions. Whilst there is a growing body of evidence around the more well-known analyzers, there are many 'new kids on the block' with new features, such as displaying the presence of potential Hb-variants, which do not yet have a proven track record.
Methods: The study is a comprehensive analytical and usability study of six POC analyzers for HbA using Clinical and Laboratory Standards Institute (CLSI) protocols, international quality targets and certified International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) and National Glycohemoglobin Standardization Program (NGSP) Secondary Reference Measurement Procedures (SRMP).
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