Health-Related Quality of Life in Individuals with Crohn's Disease: A Sample from Saudi Arabia.

Background: This study was conducted to compare health-related quality of life between adults with Crohn's disease (CD) and healthy controls (CONs).

Methods: A comparative cross-sectional study was conducted on adults with CD and CONs in Saudi Arabia (aged 18-60 years). Sociodemographic data (area of residence, education level, employment, and marital status) were collected from both groups, as well as additional information including disease onset, treatment, and symptomology from the CD group. The validated Arabic version of the quality of life tool was used to assess health-related quality of life.

Results: A total of 109 CD patients and 370 CONs participated in this study. The patients with CD had significantly lower health-related quality of life scores for physical functioning [CD 75 (50-90), CON 85 (60-95)], role physical [CD 50 (0-100), CON 100 (50-100)], role emotional [CD 67 (0-100), CON 67 (33-100)], vitality [CD 50 (30-58), CON 50 (40-60)], social functioning [CD 63 (50-75), CON 75 (50-88)], bodily pain [CD 70 (45-90), CON 80 (68-100)], and general health [CD 55 (40-65), CON 65 (55-75)]. The physical and mental domain scores were lower in the CD group [63 (52-75) and 51 (32-69)] than CONs group [75 (63-85) and 63 (55-72)], respectively (p<0.02).

Conclusion: The CD group had a lower health-related quality of life than the CONs.