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Temporal ablation of the ciliary protein IFT88 alters normal brainwave patterns.
Sci Rep
January 2025
Department of Molecular, Cellular, and Biomedical Sciences, College of Life Sciences and Agriculture, University of New Hampshire, Durham, NH, 03824, USA.
Article Synopsis
- The primary cilium is a crucial organelle involved in various signaling pathways, and its dysfunction is linked to conditions like Bardet-Biedl syndrome, Alzheimer's, and autism, all of which can lead to cognitive impairment.
- Researchers studied the effects of temporarily disabling the IFT88 gene, vital for cilia formation, in adult mice to understand cilia's role in brain activity.
- The findings showed that mice lacking functional cilia had significant learning deficits and abnormal brainwave patterns, emphasizing the importance of primary cilia for proper neural function and memory in adults.
NEK4 modulates circadian fluctuations of emotional behaviors and synaptogenesis in male mice.
Nat Commun
October 2024
Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
GWASs have linked the 3p21.1 locus, which is associated with the expression levels of NEK4, to bipolar disorder. Here, we use integrative analyses of GWAS statistics and eQTL annotations to establish that elevated NEK4 expression in the hippocampus is associated with an increased risk of bipolar disorder.
View Article and Find Full Text PDFHow Bud Craig's Insights Reshape the Research on Pain and Mind-Body Therapies.
Curr Top Behav Neurosci
October 2024
Department of Family and Community Medicine, Osher Center for Integrative Health, University of California, San Francisco, San Francisco, CA, USA.
Article Synopsis
- Bud Craig's research established the neural basis for interoception and redefined pain as a homeostatic emotion, impacting our understanding of emotions and pain through prediction processing.
- The chapter highlights mind-body therapies like meditation, yoga, and Tai Chi as effective non-drug treatments for chronic pain, supported by clinical guidelines.
- Craig's contributions have significantly shaped contemporary research on mind-body therapies, emphasizing the importance of interoceptive processes in addressing various clinical conditions, particularly pain management.
High Body Mass Index Disrupts the Homeostatic Effects of Pain Inhibitory Control in the Symptomatology of Patients With Fibromyalgia.
J Pain
December 2024
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:
Article Synopsis
- This study looks at how body mass index (BMI) impacts the relationship between sensory pain testing and clinical symptoms in fibromyalgia syndrome (FMS).
- It finds that higher BMI, particularly being overweight or obese, affects how pain response mechanisms relate to symptoms like depression, and this influence is not seen in normal-weight individuals.
- The research emphasizes the importance of considering BMI in FMS treatment strategies, suggesting that high BMI disrupts the body’s ability to manage pain, which can worsen overall health outcomes.
Meta-learning modeling and the role of affective-homeostatic states in human cognition.
Behav Brain Sci
September 2024
Faculty of Religious Sciences and Philosophy, Temuco Catholic University, Temuco,
The meta-learning framework proposed by Binz et al. would gain significantly from the inclusion of affective and homeostatic elements, currently neglected in their work. These components are crucial as cognition as we know it is profoundly influenced by affective states, which arise as intricate forms of homeostatic regulation in living bodies.
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