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Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53.
Cell Death Differ
December 2024
Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.
Germline inactivating mutations of the SLC25A1 gene contribute to various human disorders, including Velocardiofacial (VCFS), DiGeorge (DGS) syndromes and combined D/L-2-hydroxyglutaric aciduria (D/L-2HGA), a severe systemic disease characterized by the accumulation of 2-hydroxyglutaric acid (2HG). The mechanisms by which SLC25A1 loss leads to these syndromes remain largely unclear. Here, we describe a mouse model of SLC25A1 deficiency that mimics human VCFS/DGS and D/L-2HGA.
View Article and Find Full Text PDFDifferential effects of intrinsic- versus extrinsic-first corrective exercise programs on morphometric outcomes and navicular drop in pediatric flatfoot.
Sci Rep
December 2024
Health and Sports Medicine Department, Faculty of Sports Sciences and Health, University of Tehran, North Karegar St, P.O.B: 1439813117, Tehran, Iran.
Although the connection between muscular strength and flatfoot condition is well-established, the impact of corrective exercises on these muscles remains inadequately explored. This study aimed to assess the impact of intrinsic- versus extrinsic-first corrective exercise programs on muscle morphometry and navicular drop in boys with flexible flatfoot. Twenty-five boys aged 10-12 with flexible flatfoot participated, undergoing a 12-week corrective exercise program, with a shift in focus at six weeks.
View Article and Find Full Text PDFUsefulness of the "En face view" method for diagnosing perimembranous ventricular septal defects.
J Echocardiogr
December 2024
Division of Cardiovascular Surgery, Nagano Children's Hospital, Nagano, Japan.
Background: Perimembranous ventricular septal defect (VSD) can be classified as having trabecular, inlet, or outlet extension. The surgical approach used in patch closure depends on the which valve of the tricuspid valve to suture around and the avoidance of the specialized conducting system. This retrospective study evaluated the usefulness of the "En face view" method for classifying perimembranous VSD.
View Article and Find Full Text PDFThe Mediating Roles of Objectified Body Consciousness About Acceptance of Cosmetic Surgery Among International Students in China.
Aesthetic Plast Surg
December 2024
School of Public Health, Shandong Second Medical University, 7166 Baotong West Street, Weifang, Shandong, China.
Background: Studies on acceptance of cosmetic surgery may not be cross-culturally invariant, but little is known about it in non-Western populations. Therefore, it is necessary to develop cross-cultural research on it.
Methods: 230 international students in China aged 18-27 years (M = 21.
A closed-box kernel function for numerical simulation of transient heat conduction.
Sci Rep
December 2024
College of Electrical and Information Engineering, Quzhou University, Quzhou, 324000, China.
A new kernel function, termed the closed-box kernel function, has been developed to address numerical simulation of transient heat conduction in the same medium. Firstly, this method is versatile and not limited to specific industrial scenarios or designated materials. Secondly, the method solves the spatial temperature at each time point only once, eliminating the need for multiple iterations.
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