AI Article Synopsis

  • * The process involves using ethyl acetate (EA) as a solvent, which allows water to diffuse in and form a hollow structure within the microcapsules as the EA evaporates, resulting in surfaces with numerous pits.
  • * These EC microcapsules can effectively embed curcumin, demonstrating sustained drug release in a simulated intestinal environment, indicating potential for future applications in drug delivery systems and expanding the clinical use of curcumin.

Article Abstract

A simple and versatile strategy for controlled production of monodisperse ethyl cellulose (EC) microcapsules by a single-stage emulsification method has been developed. Monodisperse oil-in-water emulsions, obtained by a microfluidic device, are used as templates for preparing EC microcapsules. Oil-soluble ethyl acetate (EA) is miscible with water, so the interfacial mass transfer between EA and water occurs sufficiently, which leads to water molecules pass through the phase interface and diffuse into emulsion interior. Water molecules aggregate at the interface, and some merge into a large water drop in the central position of the emulsion. After evaporation of EA solvent, monodisperse EC microcapsules create large numbers of pits on the surface with a hollow structure. Curcumin is used as a model drug and embedded in the hollow structure. EC microcapsules have good, sustained drug release efficacy in a simulated intestinal environment, and the release process of EC microcapsules containing 6.14% drug-loaded capacity is fully consistent with the vitro drug release model. Such simple techniques for making EC microcapsules may open a window to the controlled preparation of other multifunctional microcapsules. Besides, it offers theoretical guidance for the study of EC microcapsules as drug carriers and expanding clinical application of curcumin.

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Source
http://dx.doi.org/10.1016/j.colsurfb.2022.112560DOI Listing

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