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| http://dx.doi.org/10.1016/j.jbc.2022.102052 | DOI Listing |
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Relationship between sphingolipids-mediated neuroinflammation and alcohol use disorder.
Pharmacol Biochem Behav
February 2024
The Second Affiliated Hospital of Xinxiang Medical University, Henan Key Laboratory of Biological Psychiatry, Xinxiang Medical University, Xinxiang, China; Department of Pathogenic Biology, School of Basic Medical Science, Xinxiang Medical University, Xinxiang, China. Electronic address:
Background: Alcohol use disorder is a chronic recurrent encephalopathy, and its pathogenesis has not been fully understood. Among possible explanations, neuroinflammation caused by the disorders of brain central immune signaling has been identified as one possible mechanism of alcohol use disorder. As the basic components of cells and important bioactive molecules, sphingolipids are essential in regulating many cellular activities.
View Article and Find Full Text PDFPhase I/IIa Trial in Advanced Pancreatic Ductal Adenocarcinoma Treated with Cytotoxic Drug-Packaged, EGFR-Targeted Nanocells and Glycolipid-Packaged Nanocells.
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EnGeneIC Ltd., Sydney, New South Wales, Australia.
Article Synopsis
- The study evaluated a new EGFR-targeted drug, E-EDV-D682/GC, in patients with advanced pancreatic ductal adenocarcinoma (PDAC) who had no other treatment options.
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Sex and diet-dependent gene alterations in human and rat brains with a history of nicotine exposure.
Front Psychiatry
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Department of Psychiatry, Texas Tech University Health Sciences Center, El Paso, TX, United States.
Introduction: Chronic nicotine exposure induces changes in the expression of key regulatory genes associated with metabolic function and neuronal alterations in the brain. Many bioregulatory genes have been associated with exposure to nicotine, but the modulating effects of sex and diet on gene expression in nicotine-exposed brains have been largely unexplored. Both humans and rodents display motivation for nicotine use and the emergence of withdrawal symptoms during abstinence.
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Department of Biopharmacy, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Influenza virus infects the host and transmits through the respiratory tract (i.e., the mouth and nose); therefore, the development of intranasal influenza vaccines that mimic the natural infection, coupled with an efficient mucosal adjuvant, is an attractive alternative to current parenteral vaccines.
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