Retinal vessels play an important role in judging many eye-related diseases, so accurate segmentation of retinal vessels has become the key to auxiliary diagnosis. In this paper, we present a Cascaded Residual Attention U-Net (CRAUNet) that can be regarded as a set of U-Nets, that allows coarse-to-fine representations. In the CRAUNet, we introduce a DropBlock regularization similar to the frequently-used dropout, which greatly reduces the overfitting problem. In addition, we propose a multi-scale fusion channel attention (MFCA) module to explore helpful information, and then merge this information instead of using a direct skip-connection. Finally, to prove the effectiveness of our method, we conduct extensive experiments on DRIVE and CHASE_DB1 datasets. The proposed CRAUNet achieves area under the receiver operating characteristic curve (AUC) of 0.9830 and 0.9865, respectively, for the two datasets. Compared to other state-of-the-art methods, the experimental results demonstrate that the performance of the proposed method is superior to that of others.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105651 | DOI Listing |
Pathol Res Pract
December 2024
Department of Pathology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Background: Patients with high-grade serous carcinoma (HGSC) are commonly diagnosed at late disease stages and after primary tumors have disseminated in the peritoneum. The overexpression of tight junction proteins has been associated with poor prognosis in this setting, potentially reflecting the tumor´s adaptive changes in the disease cascade.
Methods: By performing immunohistochemistry in a large single-center cohort of a total of 705 HGSC, we test the hypothesis that the protein expression of PReferentially expressed Antigen of MElanoma (PRAME) contains prognostic, predictive or clinically translatable information.
Int J Biol Macromol
December 2024
School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:
The cascade of sugar isomerases is one of the most practical methods for producing rare sugars, and enzyme immobilization endows it with high economic efficiency, operational convenience and reusability. However, the most employed cross-linker glutaraldehyde (GA) has the disadvantages of enzyme deactivation and limitation of substrate binding. Herein, three compounds, glyoxal, GA, and 2,5-furandicarboxaldehyde (DFF) were evaluated within a previously developed cascade comprising ribose-5-phosphate isomerase and D-tagatose-3-epimerase to prepare D-ribulose form D-xylose.
View Article and Find Full Text PDFActa Biomater
December 2024
National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. It is primarily caused by the proliferation, migration, and adhesion of residual lens epithelial cells within the capsular bag following phacoemulsification and intraocular lens (IOL) implantation. Although investigations of surface modification onto IOL have partially reduced PCO development in recent years, there are still challenges in long-term efficacy and intraocular biocompatibility.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Institute of Coastal Environmental Pollution Control, Key Laboratory of Marine Environment and Ecology, Frontiers Science Center for Deep Ocean Multispheres and Earth System, Ocean University of China, Qingdao 266100, China; Laboratory for Marine Ecology and Environmental Science, Qingdao Marine Science and Technology Center, Qingdao 266237, China. Electronic address:
Transformation is a crucial process determining the lifespan and risk of MoS nanomaterial during usage and after disposal. This study revealed the degradation of MoS in the presence of HO using experimental and computational methods. Experimental results showed that MoS nanosheets were degraded by 45.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.
The thermal safety issues of currently available Ni-rich cathode-based power supplies brought in the development of all-solid-state batteries, yet the cascade reactions in Ni-rich materials and the chemo-mechanical degradation between the cathode and solid electrolyte diminished the cycle life. Here, by introducing a new heteroatom chemical competing diffusion strategy, we successfully stabilize the Ni-rich cathode and the contact face with an solid electrolyte. Combining extensive explorations in theoretical calculation and multiscale in/ex situ characterization, we elucidate the atomic-level chemical competing diffusion upon the topological lithiation of layered materials.
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