In this paper, a novel structure of double gate tunnel FET has been proposed and simulated for biosensing applications. The device uses III-V compound semiconductors and an n+ doped pocket at the source channel junction. Biomolecules of different dielectric constants (K) with different charge densities (Nbio), both negative and positive, are inserted in the nano-gap cavities (15 nm ×1.5 nm) that have been created under gates near source channel junction to capture biomolecules. From extensive 2D simulations, ION sensitivity of 4.351 ×10/1.03 ×10/1.514 ×10 , subthreshold swing sensitivity of 15.67/20.21/18.57 mV/dec, and threshold voltage sensitivity of 18/12/23 mV for neutral (K = 12)/negatively charged biomolecules ( [Formula: see text] C/cm2, K = 12)/positively charged biomolecules ( [Formula: see text] C/cm2, K = 12) respectively has been observed. Also, transconductance sensitivity of 9.74 ×10 and ION/IOFF sensitivity of 5.255 ×10 for neutral biomolecules (K = 12) has been calculated. Furthermore, the device performance with one-third filled cavities, two-third filled cavities and fully filled cavities has also been studied. The performance of the proposed biosensor has been compared with the previously published work and it has been observed that the sensitivity of the proposed biosensor is 100 times better than the best reported biosensor.
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http://dx.doi.org/10.1109/TNB.2022.3178763 | DOI Listing |
Front Med (Lausanne)
January 2025
Department of General Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
(AL), a prevalent nematode causing ascariasis, infects millions worldwide, with a higher risk in preschool and school-aged children. Though infections are usually mild, rare and life-threatening complications like gastrointestinal perforation exist. This article documents a case involving a 61-year-old deaf-mute man who presented with a month-long history of epigastric pain accompanied by nausea, anorexia, and constipation.
View Article and Find Full Text PDFRegen Biomater
December 2024
Orthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215008, P. R. China.
Osteoarthritis (OA) is a frequent chronic illness in orthopedics that poses a major hazard to patient health. cell therapy is emerging as a therapeutic option, but its efficacy is influenced by both the inflammatory milieu and the amount of stem cells, limiting its use. In this study, we designed a novel injectable porous microsphere (PM) based on microfluidic technology that can support mesenchymal stem cells (MSCs) therapy by combining polylactic-glycolic acid copolymer, kartogenin, polydopamine, stromal cell-derived factor-1, and copper-doped bioactive glass (CuBG).
View Article and Find Full Text PDFRSC Adv
January 2025
Institute of Fundamental Physics (AbinitSim Unit, ABINITFOT Group), Consejo Superior de Investigaciones Científicas (CSIC) E-28006 Madrid Spain
The unique structural properties of zeolites make them ideal environments for encapsulating subnanometric metal clusters on their microporous channels and cavities, showing an enhanced catalytic performance. As a first step towards the functionalization of these clusters as photocatalysts as well, this work addresses the optical properties of zeolite-encapsulated Cu-TiO nanoparticles as well as their application in the photo-induced activation of CO by sunlight. Model density functional theory (DFT) calculations indicate the stability of the Cu cluster adsorbed on the TiO nanoparticles filling the pores of a model zeolite structure.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart 70569, Germany.
The emerging new generation of small-scaled acoustic microrobots is poised to expedite the adoption of microrobotics in biomedical research. Recent designs of these microrobots have enabled intricate bioinspired motions, paving the way for their real-world applications. We present a multiorifice design of air-filled spherical microrobots that convert acoustic wave energy to efficient propulsion through a resonant encapsulated microbubble.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Faculty of Medicine, University of Damascus, Damascus, Syrian Arab Republic.
Introduction: Mesenchymal chondrosarcoma (MC) is a high-grade variant of chondrosarcoma, essentially composed of poorly differentiated spindle cells interspersed with areas of cartilage or chondroid matrix. MC is extremely rare; it only accounts for 0.1 % of head and neck tumors and for only 1 % of all chondrosarcomas (CSs).
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