AI Article Synopsis
- Chronic inflammation may play a role in the development of differentiated thyroid cancer (DTC), and dietary choices might influence this inflammation.
- The study followed over 450,000 participants in the EPIC cohort for an average of 14 years, identifying 712 new DTC cases to explore the relationship between specific dietary inflammatory scores and DTC risk.
- Findings indicated that higher dietary inflammatory index scores were slightly associated with increased DTC risk, while the Inflammatory Score of the Diet showed no significant link, suggesting the need for further validation of these results.
Article Abstract
Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk.
Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII) and two energy-adjusted derivatives (the E-DII and the E-DII), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models.
Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16).
Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.
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| http://dx.doi.org/10.1007/s00394-022-02897-w | DOI Listing |
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