True thymic hyperplasia results from stressful situations such as chemotherapy. It commonly presents as an anterior mediastinal mass; cervical location is exceptional. Here we report a case of a cervical true thymic hyperplasia in a 12-year-old girl who had a Hodgkin lymphoma treated by radiotherapy and chemotherapy. She was referred to our department for a left cervical mass. The PET scan showed a hypermetabolic adenopathy. Mediastinal MRI was unremarkable. The patient underwent resection of the cervical mass under general anesthesia. Pathological examination confirmed the diagnosis of a true thymic hyperplasia. The aim of this paper is to illustrate a case of an incidental ectopic cervical thymic hyperplasia in a patient treated for Hodgkin lymphoma.
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http://dx.doi.org/10.1177/01455613221106214 | DOI Listing |
Immunol Invest
December 2024
Department of thoracic surgery, West China Hospital of Sichuan University, Chengdu, China.
Background: Immune homeostasis plays a crucial role in immunology andis dependent on both central and peripheral tolerance. Centraltolerance and peripheral tolerance occur in the thymus and thesecondary lymphoid tissues, respectively. Tolerance breakdown andimmune regulation defects can lead to autoimmune disorders.
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December 2024
Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
Introduction: Reactivation of thymopoiesis in adult patients with autoimmune disorders treated with autologous haematopoietic stem cell transplantation (AHSCT) is supported by studies exploring immunoreconstitution. Radiological evidence of thymic hyperplasia after AHSCT was previously reported in patients with systemic sclerosis, but, to our knowledge, it has not been described in multiple sclerosis (MS), where premature thymic involution has been observed and immunosenescence might be accelerated by disease-modifying treatments (DMTs).
Participants And Methods: monocentric case series including MS patients who performed a chest CT scan for clinical purposes after having received AHSCT (BEAM/ATG regimen) for aggressive MS failing DMTs.
Zhonghua Zhong Liu Za Zhi
November 2024
Department of Pathology, Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong (Shenzhen), Longgang District People's Hospital of Shenzhen, Shenzhen518172, China.
Orphanet J Rare Dis
December 2024
Huashan Rare Disease Centre and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Centre for Neurological Disorders, Fudan University, Shanghai, 200040, China.
J Cardiothorac Surg
November 2024
Department of Cardiothoracic Surgery, Dehong People's Hospital, Affiliated Dehong Hospital of Kun Ming Medical University, No.13, Yonghan Street, Dehong, Yunnan, 678400, China.
Background: With the continuous development of minimally invasive thoracic surgery, thoracoscopic thymectomy has become a routine operation. This method, now widely recognized, better protects lung function, reduces intraoperative blood loss and pain, and shortens postoperative hospital stay. We now introduce a standardized right thoracic incision for thoracoscopic thymic tumor resection, which has achieved favorable clinical outcomes.
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