AI Article Synopsis
- The study aimed to evaluate the effectiveness of the ISTH-BAT (Bleeding Assessment Tool) in diagnosing Glanzmann Thrombasthenia (GT) by comparing scores of patients to healthy controls.
- Conducted at The Children's Hospital in Lahore over nine years, the research involved 133 GT patients and 75 healthy controls to analyze bleeding symptoms and ISTH-BAT scores retrospectively.
- Results showed that GT patients had significantly higher ISTH-BAT scores, indicating that the tool is valuable for diagnosing the condition, with a sensitivity of 86.4% and specificity of 77.3%.
Article Abstract
Objectives: To assess the utility of ISTH-BAT (International Society on Thrombosis and Hemostasis- Bleeding Assessment Tool) in the diagnosis of Glanzmann Thrombasthenia (GT) in comparison to controls.
Methods: It was a case-control study carried out at The Children's Hospital, Lahore from January 2012 to May 2021. All patients from neonates to 18 years with a final diagnosis of GT were studied retrospectively. The clinical details were collected from hospital records and telephonically on ISTH-BAT questionnaire after taking informed consent. The same proforma was obtained from 75 healthy controls. Data was analyzed on SPSS version 26.
Results: Out of 427 patients with suspected platelet function disorders, 133 were diagnosed as GT. The mean age was 7.29±5 years. Male to female ratio was 1.1:1. Among cases, 76.6% were products of consanguineous marriage. Epistaxis was the commonest symptom with highest score (p value<0.001). Cutaneous and oral cavity bleeds were more severe and frequent in patients than controls (p value < 0.004). The median ISTH-BAT score among patients was nine while in control group was one. Sensitivity was 86.4%, specificity was 77.3%, positive predictive value was 0.87 and negative predictive value was 0.76. Area under the receiver operator curve was 0.78 (95% confidence interval 0.82-0.90, p< 0.001*).
Conclusion: ISTH-BAT scores were significantly higher in GT patients than controls. So, we recommend the inclusion of ISTH-BAT in diagnostic evaluation of patients with suspected Glanzmann Thrombasthenia.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121956 | PMC |
| http://dx.doi.org/10.12669/pjms.38.4.5361 | DOI Listing |
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