Metagenome Sequencing Reveals the Microbiome of and Its Possible Relationship With Dengue Virus Susceptibility.

Dengue fever virus (DENV) is a mosquito-borne flavivirus that poses a serious risk to human health. is a widely distributed vector of dengue fever in China. Based on the impact of physiological activity, the microbiome in will provide a novel environment-friendly approach to control DENV transmission. We performed metagenomic sequencing on before and after exposure to DENV blood meal to detect microbiome variation of with different susceptibilities to DENV. The dominant phyla in microbiome were and , and the dominant genera were and . , , and differed significantly after DENV infection. There were 15 different microorganisms found to be involved in mosquito immunity and metabolism, such as , , and , which might have an impact on the DENV susceptibility of . It was hypothesized that the lack of specific bacteria may lead to increased susceptibility of to DENV. Interventions in the microbiome composition or specific bacteria of may affect the susceptibility to DENV and control the mosquito-borne diseases efficiently.