Introduction: Chickenpox is an acute, highly infectious disease. Outbreaks can occur in adults in closed institutional settings like hostels and barracks. This study aims to report varicella zoster outbreak among male military personnel in a military training centre.
Methods: An outbreak investigation of chickenpox in a military training school and tertiary hospital was conducted. Ethical approval was taken from the Institutional Review Committee (Reference number: 267). Data was collected from February 5, 2020 to April 10, 2020 by questionnaire and clinical examination. Case definitions were prepared as per the Centre for Disease Control and Prevention criteria. Data was entered and analysed in Microsoft Excel 2010.
Results: Out of the 167 male personnel in the training centre, 90 (53.89%) were susceptible to varicella and 84 (50.29%) were close contacts. The secondary attack rate of varicella zoster was 21.43% (18 cases). The mean age of the patients was 22.33±1.72 years. The mean days of admission were 5±2.28 days. The most common clinical features were generalised rash in 18 (100%), fever in 15 (83.33%), and body ache in 12 (66.67%) cases.
Conclusions: Natural history, clinical, and epidemiological features of varicella zoster in a closed institutional setting was studied with the secondary attack rate being less as compared to other studies.
Keywords: chickenpox; military; outbreak.
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http://dx.doi.org/10.31729/jnma.7440 | DOI Listing |
Hereditas
January 2025
The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, No. 182 Chunhui Road, Longmatan District, Luzhou, Sichuan, 646000, China.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, with antibody-mediated immune responses to infectious diseases agents potentially playing a decisive role in its pathophysiological process. However, the causal relationship between antibodies and AD remains unclear.
Methods: A two-sample Mendelian randomization (MR) analysis was conducted to investigate the causal link between antibody-mediated immune responses to infectious diseases agents and the risk of AD.
Alzheimers Dement
December 2024
Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
Background: Early Onset Alzheimer's Disease (EOAD) is thought to result from a combination of environmental, genetic, and lifestyle factors. Herpesvirus infections may contribute to the development of EOAD and the objective of our study is to identify potential associations between herpes virus infections and the risk of developing EOAD.
Method: Amyloid-status Alzheimer's disease was diagnosed based on clinical history and ATN criteria, determined by the measuring the Amyloidß42:40 ratio, tau, and 181-Phospho-tau in the cerebrospinal fluid.
Acta Derm Venereol
January 2025
Ben Gurion University of the Negev, Faculty of Health Sciences, Beer-Sheva, Israel; Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel.
This study investigates serum cell-free DNA fluctuations in patients with herpes zoster or post-herpetic neuralgia, offering insight into the tissue damage and inflammatory dynamics associated with these conditions. A single-centre combined cross-sectional and longitudinal study was conducted with 59 patients to assess cell-free DNA levels in herpes zoster and post-herpetic neuralgia. Cell-free DNA was extracted from blood samples of patients with herpes zoster or post-herpetic neuralgia and compared with healthy controls.
View Article and Find Full Text PDFInt J Emerg Med
January 2025
Emergency Department, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Background: Ramsay Hunt syndrome (RHS), a rare complication of varicella-zoster virus (VZV) reactivation, presents with ipsilateral facial paralysis, ear pain, and vesicular rash. Early recognition is crucial for prompt treatment and optimal outcomes.
Case Presentation: We report a case of a 67-year-old woman with RHS who presented with right-sided facial palsy, severe ear pain, and fluid-filled blisters.
Inn Med (Heidelb)
January 2025
Medizinischen Klinik I, Agaplesion Markus Krankenhaus, Wilhelm-Epstein-Str. 4, 60431, Frankfurt/Main, Deutschland.
Background: The treatment options for chronic inflammatory bowel diseases (IBD) have been greatly expanded due to a better understanding of the underlying pathogenesis. A total of five classes of advanced treatment are available.
Objective: A practical overview of advanced treatment of IBD.
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