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Comparative evaluation of peptide vs. protein-based calibration for quantification of cardiac troponin I using ID-LC-MS/MS.
Clin Chem Lab Med
January 2025
70777 TUBITAK National Metrology Institute (TUBITAK UME), Kocaeli, Türkiye.
Objectives: An analytical protocol based on isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS), which includes a peptide-based calibration strategy, was developed and validated for the determination of cardiac troponin I (cTnI) levels in clinical samples. Additionally, the developed method was compared with a protein-based calibration strategy, using cTnI serving as a model for low-abundant proteins. The aim is to evaluate new approaches for protein quantification in complex matrices, supporting the metrology community in implementing new methods and developing fit-for-purpose SI- traceable peptide or protein primary calibrators.
View Article and Find Full Text PDFCorrigendum: Anti-cancer immune effect of human colorectal cancer neoantigen peptide based on MHC class I molecular affinity screening.
Front Immunol
December 2024
Department of Urology, Huaihe Hospital of Henan University, Kaifeng, China.
[This corrects the article DOI: 10.3389/fimmu.2024.
View Article and Find Full Text PDFImproving Differentiation of Crohn's Disease and Ulcerative Colitis Proteomes through Protein-Wide Association Study Feature Selection in Machine Learning.
medRxiv
November 2024
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Background And Aims: Diagnostic differentiation between Crohn's disease (CD) and ulcerative colitis (UC) is crucial for timely and suitable therapeutic measures. The current gold standard for differentiating between CD and UC involves endoscopy and histology, which are invasive and costly. We aimed to identify blood plasma proteomic signatures using a Protein-Wide Association Study (PWAS) approach to differentiate CD from UC and evaluate the efficacy of these signatures as features in machine learning (ML) classifiers.
View Article and Find Full Text PDFAuthor Correction: Catalytic peptide-based coacervates for enhanced function through structural organization and substrate specificity.
Nat Commun
November 2024
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157, Oeiras, Portugal.
Peptides in the Treatment of Gastric Ulcer.
Bull Exp Biol Med
November 2024
Altai State Medical University, Barnaul, Russia.
A promising area in the search for effective and safe methods of pharmacotherapy for gastric ulcers is the study of bioactive substances of natural origin and derivatives synthesized on the basis of these substances. The review presents modern information on various peptide-based substances that are pharmacologically active against gastric ulcer, including analogues of natural neuropeptides, synthetic substances with a specific amino acid sequence, as well as drugs derived from biological peptide complexes. Based on the results of the analysis, we have assessed the prospects of this pharmacological approach and outlined the areas for further research.
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