AI Article Synopsis
- The study introduces pro-antimicrobial networks called PANDAs, which release bioactive aldehydes when degraded.
- PANDAs are created from a specific acetal and efficiently release a powerful antibacterial and antifungal compound under mild conditions (like neutral pH and high humidity).
- These networks provide customizable release rates, effectiveness against microbes without fostering resistance, and low toxicity to human cells.
Article Abstract
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl -chlorobenzaldehyde acetal degrade and release -chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.
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| http://dx.doi.org/10.1021/acsmacrolett.7b00009 | DOI Listing |
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