AI Article Synopsis
- Human cytomegalovirus (HCMV) can lead to severe diseases like pneumonia in HIV-exposed infants, influenced by complex viral factors such as its large genome and variability.
- Whole genome sequencing was used to analyze HCMV infections in HIV-exposed infants and compare them with lung transplant recipients and patients with blood disorders.
- Results showed that HIV-exposed infants had a higher prevalence of multiple HCMV strains, with certain genotypes like UL73 G4B and UL74 G4 being more common, although conclusions on strain compartmentalization in the lungs were inconclusive.
Article Abstract
Human cytomegalovirus (HCMV) can cause significant end-organ diseases such as pneumonia in HIV-exposed infants. Complex viral factors may influence pathogenesis including: a large genome with a sizeable coding capacity, numerous gene regions of hypervariability, multiple-strain infections, and tissue compartmentalization of strains. We used a whole genome sequencing approach to assess the complexity of infection by comparing high-throughput sequencing data obtained from respiratory and blood specimens of HIV-exposed infants with severe HCMV pneumonia with those of lung transplant recipients and patients with hematological disorders. There were significantly more specimens from HIV-exposed infants showing multiple HCMV strain infection. Some genotypes, such as UL73 G4B and UL74 G4, were significantly more prevalent in HIV-exposed infants with severe HCMV pneumonia. Some genotypes were predominant in the respiratory specimens of several patients. However, the predominance was not statistically significant, precluding firm conclusions on anatomical compartmentalization in the lung.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147013 | PMC |
| http://dx.doi.org/10.3390/v14050855 | DOI Listing |
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