Background: Two years into the pandemic, vaccination remains the most effective option to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Preliminary studies suggest vaccination efficacy in patients with inflammatory bowel diseases (IBD), but little is known about its impact on chronic intestinal inflammation. Here we assessed the mucosal inflammatory activity in patients with IBD before and after immunization with the mRNA-1273 (Moderna) vaccine by measurement of fecal calprotectin (fCP).
Methods: In 42 patients with IBD, the baseline fCP levels obtained prior to the first vaccine were compared with the highest levels measured during and after two doses of vaccination. Patients' sera were collected after the second dose to evaluate anti-SARS-CoV-2 antibodies' titers.
Results: We observed a significant fCP elevation in 31% of patients after any dose. Vedolizumab was identified as the only agent associated with an fCP increase (OR 12.4, 95% CI [1.6; 120.2], = 0.0171). Gastrointestinal adverse events were reported in 9.5% of all subjects and in 75% of cases accompanied by an fCP increase. Anti-SARS-CoV-2 antibodies associated only weakly with the fCP increase after the first dose ( = 0.04).
Conclusions: Our findings support possible collinearity in pathways of SARS-CoV-2 antigen expression and the pathogenesis of IBD.
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| http://dx.doi.org/10.3390/vaccines10050759 | DOI Listing |
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View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to determine the reference interval (RI) for fecal calprotectin (fCP) levels and fCP:protein ratios in healthy horses to assess their potential for diagnosing intestinal inflammation in horses with colic and colitis.
- - Fecal samples were analyzed from 103 healthy horses and 28 horses with intestinal conditions, revealing that colitis cases had significantly higher fCP levels and fCP:protein ratios compared to healthy horses and colic cases.
- - The findings suggest that elevated fCP and fCP:protein ratios could be indicative of colitis but further research is necessary to develop reliable diagnostic tests for equine intestinal inflammation.
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