AI Article Synopsis
- The study investigates the anticancer potential of a well-known African shrub, leveraging nanotechnology to improve the delivery of its bioactive extract.
- Researchers tested the extract's effects on various human cancer cell lines, finding notable cytotoxic activity in both lab models and actual cancer cells.
- While the shrub exhibited anticancer properties, it experienced reduced effectiveness when encapsulated in PLGA nanoparticles, primarily due to the sustained release mechanism.
Article Abstract
is an African well-known shrub recognized for numerous medicinal properties, including its cancer management potential. The advent of nanotechnology in delivering bioactive medicinal plant extract with poor solubility has improved the drug delivery system, for a better therapeutic value of several drugs from natural origins. This study aimed to evaluate the anticancer properties of using human lung (H460), breast (MCF-7), and colon (HCT 116) cancer cell lines as well as the production, characterization, and cytotoxicity study of loaded into PLGA nanoparticles. Benchtop models of and were used for preliminary toxicity evaluation. Notable cytotoxic activity in benchtop models and human cancer cell lines was observed for crude extract. The PLGA nanoparticles loading had a size of about 200 nm and an association efficiency of above 60%, making them suitable to be delivered by different routes. The outcomes from this research showed that has anticancer activity as claimed from an ethnomedical point of view; however, a loss in activity was noted upon encapsulation, due to the sustained release of the drug.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147688 | PMC |
| http://dx.doi.org/10.3390/ph15050535 | DOI Listing |
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