Department of Pharmaceutical Botany, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, HR-10000 Zagreb, Croatia.
Published: April 2022
AI Article Synopsis
Article Abstract
Species from the genus L. have been used as healing agents for various ailments, with utilization of L. being most frequently reported. The aim of this study was to evaluate the antidiabetic, antioxidant, anti-inflammatory, antibacterial and anticancer potential of and three related species, Lapeyr., L. and (Podp.) O.Schwarz, in relation to their phytochemical compositions. Globularin and verbascoside were identified using LC-PDA-ESI-MS as the major metabolites of with known biological activities. demonstrated the greatest α-glucosidase inhibitory activity and DPPH radical scavenging activity (IC = 17.25 μg/mL), while its anti-inflammatory activity was not significantly different from those of related species. All investigated species showed considerable antibacterial activity against methicillin-resistant in the broth microdilution method (MIC = 1.42-3.79 mg/mL). also showed antibacterial activities against (MIC = 1.42 mg/mL), (MIC = 1.89 mg/mL), (MIC = 2.84 mg/mL) and (MBC = 5.68 mg/mL). , and showed greater anticancer potential than . Obtained results indicate investigated species could serve as sources of diverse bioactive molecules, with having the greatest antibacterial potential.
NHS North West Genomic Medicine Service Alliance, UK; Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester, UK; The Division of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester, UK.
In 2020, the introduction of pre-emptive DPYD genotyping prior to the administration of systemic fluoropyrimidine-based chemotherapy represented one of the first widespread pharmacogenetic testing programmes to be applied nationally in the United Kingdom. Pharmacogenetic variants in the DPYD gene found in between 3 and 6% of the population are a recognised cause of primary DPD enzyme deficiency and associated increased risk of severe fluoropyrimidine toxicity [1]. Yet, the availability of testing globally is heterogeneous.
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology & School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, China; Innovation Center for Vaccine Engineering, Jiangnan University, Wuxi, 214122, China. Electronic address:
The bidentate metal ion chelator 8-hydroxyquinoline (8-HQ) demonstrates significant potential in anticancer therapy but is hindered by adverse effects due to nonspecific chelation in normal tissues. The phenolic hydroxyl oxygen of 8-HQ has been extensively exploited to develop O-masked 8-HQ prodrugs aimed at achieving on-demand chelation. However, the equally crucial quinoline nitrogen for chelation remains underutilized.
A novel method for synthesizing nanomaterials involves microbial or phytochemical nano-factories, which offer an eco-friendly, cost-effective, and reliable approach to producing clean and reproducible products. In this study, magnesium oxide nanoparticles (MgO NPs) were synthesized using Avicennia marina, a marine plant, as both a nucleation and stabilizing agent. The MgO NPs were characterized for crystallinity, cut-off wavelength, morphology, thermal stability, and surface properties using XRD, EDX, BET, UV-Visible spectroscopy, DLS, zeta potential analysis, SEM, TEM, TGA/DTA, and PL spectroscopy.
Introduction: Methyltransferase-like protein 3 (METTL3), in complex with METTL14, is the key 'writer' protein for RNA mA methylation, accounting for almost all mRNA mA modifications. Recent studies reveal that METTL3 is implicated in the development and progression of various types of cancers. Targeting METTL3 with small molecule inhibitors represents a promising therapeutic strategy for cancer.
Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.
DNA interstrand cross-links (ICLs) are the sources of the cytotoxicity of many anticancer agents. Selenium compounds showed great potential as anticancer drugs. In this work, we synthesized a binaphthalene analog containing phenyl selenide (-SePh) as the leaving group and investigated its photochemical reactivity toward DNA as well as its cytotoxicity and selectivity.
