AI Article Synopsis
- The study aimed to examine how the microbiota composition changes in coeliac disease (CD) patients following a gluten-free diet (GFD).
- Researchers analyzed 13 out of 843 papers, involving 212 CD patients on GFD, 174 healthy individuals, and 176 untreated CD patients, using faecal samples and duodenal biopsies.
- Results showed that while GFD did not completely restore normal microbiota levels, it increased beneficial bacteria and decreased harmful bacteria, helping improve CD symptoms.
Article Abstract
The aim of this study was to assess the changes in microbiota composition during a gluten-free diet (GFD) in coeliac disease (CD) patients. The systematic search followed databases such as PUBMED (MEDLINE), SCOPUS, WEB OF SCIENCE and EMBASE. Out of 843 initially screened papers, a total number of 13 research papers were included. A total of 212 patients with CD on GFD, in comparison to 174 healthy individuals and 176 untreated patients with CD, were examined. Analysis of the microbial community based primarily on faecal samples and duodenal biopsies. was noticed to be less abundant in the study group than in both control groups, while the abundance of was more numerous in the group of CD patients on GFD. prevailed in untreated CD patients. Despite the fact that the GFD was not able to fully restore commensal microorganism abundance, the treatment was associated with the greater abundance of selected beneficial bacteria and lower presence of pathogenic bacteria associated with worsening of CD symptoms.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147811 | PMC |
| http://dx.doi.org/10.3390/nu14102083 | DOI Listing |
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