A new effective method for the synthesis of imidazo[1,5-]pyridazines derivatives (yields = 68-89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed. The course of reaction has been examined by classical organic methods, HPLC-MS analysis, and quantum-chemical calculations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147549 | PMC |
| http://dx.doi.org/10.3390/molecules27103326 | DOI Listing |
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