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GLP-1 receptor agonists and retained gastric content: Is it much ado about nothing?
Obesity (Silver Spring)
January 2025
Mayo Clinic, Rochester, Minnesota, USA.
Endoscopy and Anesthesia Outcomes Associated with Glucagon-Like Peptide-1 Receptor Agonist use in Patients Undergoing Outpatient Upper Endoscopy.
Gastrointest Endosc
January 2025
Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Division of Digestive Diseases, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH. Electronic address:
Background And Aims: Glucagon-like peptide-1 receptor agonists (GLP1RAs) can cause delayed gastric emptying, raising concern for retained gastric contents (RGCs) during endoscopy and adverse anesthesia events. We aimed to determine associations between GLP1RA and endoscopy and anesthesia outcomes.
Methods: This single-center retrospective cohort study examined patients prescribed GLP1RA who underwent outpatient endoscopy stratified by exposure at the time of endoscopy.
Synthetic Strategies for the Development of Ibuprofen Derivatives: A Classified Study.
Curr Top Med Chem
January 2025
Department of Pharmaceutical Chemistry, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, Telangana.
Ibuprofen, a widely used NSAID from the aryl propionic acid class, effectively relieves pain, fever, and inflammation. On prolonged use, it leads to gastrointestinal, hepatic, and renal toxicities, particularly gastrointestinal ulcers. These side effects are largely attributed to the carboxylic acid functional group common to NSAIDs.
View Article and Find Full Text PDFDual-responsive micromotor pill for targeted retention in the intestines .
J Mater Chem B
January 2025
Department of General Surgery, Heilongjiang Provincial Hospital, Harbin, China.
There has been considerable interest in the recent advances in synthetic micro/nanomotors in diverse biofluids due to their potential biomedical applications. However, the propulsion of existing micro/nanomotor platforms for delivery in the gastrointestinal (GI) tract is inefficient. Herein, we present a magnetically and chemically actuated micromotor-tableted pill that can be actively retained in the GI tract .
View Article and Find Full Text PDF"INSERT-COIN": A PROSPECTIVE STUDY OF COIN INGESTION IN CHILDREN OF SOUTHERN ITALY.
Am J Gastroenterol
December 2024
Pediatric Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, 06123 Perugia, Italy.
Background And Aims: Coins are the most commonly ingested foreign bodies. When they get stuck in the distal esophagus there is no general agreement about the timing of their removal, since some of them may spontaneously migrate into the stomach, no longer requiring removal. We aimed at evaluating the gastric spontaneous passage of esophageal-retained coins, as well as complications.
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