AI Article Synopsis

  • A new electrochemical sensor using hierarchical carbon nanofibers with nickel and cobalt nanoparticles was developed, showcasing high sensitivity and good electrical properties.
  • The sensor demonstrated reproducibility and repeatability with relative standard deviations of 9.7% and 3.4%, respectively, and was used to accurately measure the antihistamine drug cetirizine hydrochloride (CTZ) in various concentrations.
  • The method was optimized for real sample analysis, achieving satisfactory recoveries of 97-115%, indicating its potential for routine use in laboratories.

Article Abstract

A new electrochemical sensor based on hierarchical carbon nanofibers with Ni and Co nanoparticles (eCNF/CNT/NiCo-GCE) was developed. The presented sensor may be characterized by high sensitivity, good electrical conductivity, and electrocatalytic properties. Reproducibility of its preparation expressed as %RSD (relative standard deviation) was equal to 9.7% ( = 5). The repeatability of the signal register on eCNF/CNT/NiCo-GCE was equal to 3.4% ( = 9). The developed sensor was applied in the determination of the antihistamine drug-cetirizine hydrochloride (CTZ). Measurement conditions, such as DPV (differential pulse voltammetry) parameters, supporting electrolyte composition and concentration were optimized. CTZ exhibits a linear response in three concentration ranges: 0.05-6 µM ( = 0.988); 7-32 ( = 0.992); and 42-112 ( = 0.999). Based on the calibration performed, the limit of detection (LOD) and limit of quantification (LOQ) were calculated and were equal to 14 nM and 42 nM, respectively. The applicability of the optimized method for the determination of CTZ was proven by analysis of its concentration in real samples, such as pharmaceutical products and body fluids (urine and plasma). The results were satisfactory and the calculated recoveries (97-115%) suggest that the method may be considered accurate. The obtained results proved that the developed sensor and optimized method may be used in routine laboratory practice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147852PMC
http://dx.doi.org/10.3390/ma15103648DOI Listing

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