AI Article Synopsis
- * A review of 62 interventional clinical trials demonstrates how multi-omics approaches are being used for patient stratification, diagnosis, and drug evaluation in MNDs.
- * The growing application of omics sciences in MND research is poised to revolutionize diagnosis and treatment, necessitating substantial investments for effective personalized medicine evolution.
Article Abstract
The "omics revolution" has totally changed the scientific research approach and is contributing to the development of personalized therapies. In motor neuron diseases (MNDs), a set of complex, multifactorial, late-onset and chronic neurodegenerative diseases, the use of multi-omics approaches in clinical trials is providing new opportunities to stratify patients and develop target therapies. To show how omics science is gaining momentum in MNDs, in this work, we review the interventional clinical trials for MNDs based on the application of omics sciences. We analyze a total of 62 clinical trials listed in the ClinicalTrials database where different omics approaches have been applied in an initial phase, for diagnosis or patient selection, or in subsequent stages to cluster subjects, identify molecular signatures or evaluate drugs security or efficacy. The rise of omics sciences in clinical experimentation of MNDs is leading to an upheaval in their diagnosis and therapy that will require significant investments and means to ensure the correct and rapid evolution of personalized medicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144989 | PMC |
| http://dx.doi.org/10.3390/jpm12050758 | DOI Listing |
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