AI Article Synopsis
- Researchers hypothesized a link between fetal prematurity or Intrauterine Growth Restriction (IUGR) and the factor V Leiden mutation, which may increase pregnancy complications leading to preterm births.
- A study across six years (2015-2020) tested 339 low birth weight newborns (under 1500 g) and found a significantly higher occurrence of the mutation (12.4%) compared to the average in the Czech population (5.0%).
- Despite the higher prevalence of the mutation, there was no correlation found with earlier gestational weeks, lower birth weight, or newborn sex.
Article Abstract
It has been hypothesized that fetal prematurity or Intrauterine Growth Restriction (IUGR) could be related to the presence of factor V of Leiden mutation. This mutation is associated with a higher incidence of pregnancy difficulties that can result in preterm birth. The frequency of Leiden mutation was investigated in the group of newborns with a low birth weight below 1500 g over a six-year period from 2015 to 2020. During this period, 339 newborns were tested, of which 42 newborns with V Leiden mutation (12.4%) were detected. The average of its occurrence frequency in the Czech population was determined as 5.0% based on published studies. In our research, the occurrence of the V Leiden mutation was found significantly higher in newborns under 1500 g. At the same time, we did not demonstrate an increased frequency of births at lower gestational weeks, lower birth weight, or an association with sex in newborns with a positive diagnosis of the Leiden V factor.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9140989 | PMC |
| http://dx.doi.org/10.3390/healthcare10050865 | DOI Listing |
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