-methyladenosine (mA) is a prevalent and reversible post-transcriptional RNA modification that decorates tRNA, rRNA and mRNA. Recent studies based on technical advances in analytical chemistry and high-throughput sequencing methods have revealed the crucial roles of mA RNA modification in gene regulation and biological processes. In this review, we focus on progress in the study of mA methyltransferases, mA demethylases and mA-dependent RNA-binding proteins and highlight the biological mechanisms and functions of mA RNA modification, as well as its association with human disease. We also summarize the current understanding of detection approaches for mA RNA modification.
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| http://dx.doi.org/10.3390/genes13050910 | DOI Listing |
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