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The Effects of Hindlimb Unloading of Rats on Rheographic Parameters of Femoral and Brachial Arteries In Situ.
Bull Exp Biol Med
November 2024
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathophysiology, Moscow, Russia.
Article Synopsis
- The study measured the electrical impedance and pulsation ranges of brachial and femoral arteries in rats after 14 days of hindlimb unloading (a model for microgravity).
- Results showed that the femoral artery constricted while the brachial artery dilated, with both exhibiting reduced pulsation dynamics.
- The ability of the femoral artery to switch to an active pulsatile mode during bloodletting was significantly lower in unloaded rats than in control rats, indicating potential negative effects of microgravity on blood circulation.
Retinal blood vessel diameter changes with 60-day head-down bedrest are unaffected by antioxidant nutritional cocktail.
NPJ Microgravity
November 2024
Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Loewi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.
Article Synopsis
- Long-term head-down bedrest (HDBR) simulates weightlessness and negatively impacts the retina and cerebrovascular regulation in healthy males.
- Participants experienced a decrease in retinal arteriolar diameter by day 8 and an increase in venular diameter by day 16, along with higher blood pressure and lower cerebral blood flow velocity during HDBR.
- An anti-inflammatory/antioxidant cocktail did not reverse these vascular changes, suggesting it was ineffective in restoring normal microcirculation and cerebral blood flow.
A biosensory μvessel-gravity device for advancing vascular analysis in space medicine.
Biosens Bioelectron
January 2025
Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, China; Key Laboratory of Hazard Assessment and Control in Special Operational Environment of the Ministry of Education, School of Preventive Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
Studying vascular responses to microgravity (MG) poses significant challenges in space medicine due to the limitations of conventional cell culture and animal models. To address these challenges, we have developed an innovative biosensory μvessel-gravity device that integrates organ-on-a-chip technology, 3D printing, and a 3D clinostat. This device enables cell interaction monitoring and flow shear stress modeling, thereby allowing accurate blood vessel cell sensory to changed mechanical environment.
View Article and Find Full Text PDFProteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination.
PLoS One
November 2024
State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.
Long-term exposure to a microgravity environment leads to structural and functional changes in hearts of astronauts. Although several studies have reported mechanisms of cardiac damage under microgravity conditions, comprehensive research on changes at the protein level in these hearts is still lacking. In this study, proteomic analysis of microgravity-exposed hearts identified 156 differentially expressed proteins, and ubiquitinomic analysis of these hearts identified 169 proteins with differential ubiquitination modifications.
View Article and Find Full Text PDFOxidative stress, neuroinflammation, and the blood-brain barrier biomarkers on the brain response to spaceflight.
Life Sci Space Res (Amst)
November 2024
Department of Basic Sciences, Division of Biomedical Engineering Sciences (BMES), Loma Linda University Health, Loma Linda, CA, USA.
Prolonged spaceflight can induce physiologic and pathologic abnormalities in the central nervous system (CNS). Our knowledge of the adaptive and/or detrimental effects of spaceflight on the structure and function of the nervous system is limited. Substantial effort has been devoted to identifying and developing reliable indicators to characterize and predict CNS injury and dysfunction associated with prolonged exposure to major components of the space environment including microgravity, physiological/psychological stress, and radiation from galactic cosmic rays (GCR) and solar particle events (SPEs) outside of low earth orbit (LEO).
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