Triplet-triplet annihilation upconversion (TTA-UC) nanoparticles (NPs) have emerged as imaging probes and therapeutic probes in recent years due to their excellent optical properties. In contrast to lanthanide ion-doped inorganic materials, highly efficient TTA-UC can be generated by low excitation power density, which makes it suitable for clinical applications. In the present study, we used biodegradable poly(lactic-co-glycolic acid) (PLGA)-NPs as a delivery vehicle for TTA-UC based on the heavy metal porphyrin Platinum(II) octaethylporphyrin (PtOEP) and the polycyclic aromatic hydrocarbon 9,10-diphenylanthracene (DPA) as a photosensitizer/emitter pair. TTA-UC-PLGA-NPs were successfully synthesized according to an oil-in-water emulsion and solvent evaporation method. After physicochemical characterization, UC-efficacy of TTA-UC-PLGA-NPs was assessed in vitro and ex vivo. TTA-UC could be detected in the tumour area 96 h after in vivo administration of TTA-UC-PLGA-NPs, confirming the integrity and suitability of PLGA-NPs as a TTA-UC in vivo delivery system. Thus, this study provides proof-of-concept that the advantageous properties of PLGA can be combined with the unique optical properties of TTA-UC for the development of advanced nanocarriers for simultaneous in vivo molecular imaging and drug delivery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138547 | PMC |
| http://dx.doi.org/10.3390/biomedicines10051070 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Green Synthesis of ZnO Nanoparticles Using Ficus benghalensis for Visible Light-Driven Photocatalytic Degradation of Crystal Violet and Antibacterial and Antibiofilm Activities.
Luminescence
January 2025
School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea.
Crystal Violet (CV) is a vibrant and harmful dye known for its toxicity to aquatic life and potential carcinogenic effects on humans. This study explores the removal of CV through photocatalysis driven by visible light, as well as examining the antibacterial and antibiofilm characteristics of zinc oxide nanoparticles (ZnO NPs) synthesized from the aerial roots of Ficus benghalensis. Various characterization techniques were employed to confirm the optical properties, crystal lattices, and morphology of ZnO NPs.
View Article and Find Full Text PDFOptimizing Edible Sorghum Bowls: Effects of Roasting and Edible Flower Powder Enhancement on Technological, Nutritional, Antioxidant, and Functional Properties.
Int J Food Sci
January 2025
Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara, Punjab, India.
The widespread reliance on single-use plastics (SUPs) has fostered a global throwaway culture, especially in the food packaging industry, where convenience and low cost have driven their adoption, posing serious environmental threats, particularly to marine ecosystems and biodiversity. Edible and ecofriendly packaging made from millet, specifically sorghum ( () Moench), is a promising solution to mitigate SUP consumption and promote sustainability. This study explores the development of edible sorghum bowls, enhanced through roasting and incorporating 3 g of hibiscus and rose flower powders.
View Article and Find Full Text PDFOptical, rheological, and dielectric properties of coconut oil between 100 kHz and 30 MHz.
Heliyon
July 2024
Department of Physics, University of Lucknow, Lucknow 226007, India.
In this paper, the dielectric behaviour of coconut oil within the frequency range 100 kHz to 30 MHz between temperature 30 °C-50 °C has been observed. The measured values of the dielectric constant and dielectric loss show notable variation with frequency and temperature for pure coconut oil. It is noticed that the dielectric constant (՛) and dielectric loss (՛՛) of coconut oil decreases with increasing temperature.
View Article and Find Full Text PDFA synthetic methodology toward π-extended porphyrin-rylenediimide conjugates.
RSC Adv
January 2025
Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials (ICMM), Chair of Organic Chemistry II, Friedrich-Alexander-Universität Erlangen-Nürnberg Nikolaus-Fiebiger-Str. 10 91058 Erlangen Germany
In this work, we present a straightforward synthetic route for the preparation of functionalized β--fused porphyrins, which are subsequently connected to rylendiimides. The resulting donor-acceptor-type conjugates exhibit intriguing optical properties, such as panchromatism and profoundly bathochromically shifted absorption curves. A better understanding of the molecules' electronic structure was gained through density-functional theory calculations, which unveiled small HOMO-LUMO gaps.
View Article and Find Full Text PDFDesign concepts for advanced-technology intraocular lenses [Invited].
Biomed Opt Express
January 2025
Center for Visual Science, The Institute of Optics, Flaum Eye Institute. University of Rochester, Rochester, NY, USA.
An intraocular lens (IOL) replaces the natural crystalline lens during cataract surgery, and although the vast majority of implants have simple optics, "advanced technology" IOLs have multifocal and extended depth of focus (EDOF) properties. Optical concepts are evaluated here, with image contrast, focal range, and unwanted visual phenomena being the primary concerns. Visual phenomena with earlier bifocal diffractive lenses led to alternative diffractive designs (trifocals, etc.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!