AI Article Synopsis
- Placenta-specific trophoblast cells and tumor cells share characteristics like tissue invasion and immune system evasion, which are crucial for their survival and function.
- Both cell types are influenced by their surrounding microenvironments, impacting their ability to invade, form new blood vessels (angiogenesis), and avoid detection by the immune system.
- Unlike tumor cells, trophoblast cells have more stringent regulatory mechanisms governing their metabolism, proliferation, migration, and invasiveness, leading to distinct differences in their cellular behavior.
Article Abstract
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and escape the immune system. Importantly, both trophoblast and tumor cells are supported by an abetting microenvironment, which influences invasion, angiogenesis, and immune tolerance/evasion, among others. However, in contrast to tumor cells, the metabolic, proliferative, migrative, and invasive states of trophoblast cells are under tight regulatory control. In this review, we provide an overview of similarities and dissimilarities in regulatory processes that drive trophoblast and tumor cell fate, particularly focusing on the role of the abetting microenvironments.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9138511 | PMC |
| http://dx.doi.org/10.3390/biomedicines10051065 | DOI Listing |
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