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Management of Infection and Effectiveness Rates in Daily Clinical Practice in Spain: 2010-2019. | LitMetric

AI Article Synopsis

  • * A total of 1,644 penicillin non-allergic patients were reviewed, showing a shift in preferred therapies from traditional triple therapy to more effective quadruple therapies, with usage of the single capsule Pylera rising significantly by 2019.
  • * Overall guideline adherence was 76.4%, with global eradication efficacy at 70.7%, indicating that even with newer therapies, the goal of 90% treatment effectiveness has not been met in clinical practice.

Article Abstract

The management and effectiveness of the treatment of infection are heterogeneous worldwide, despite the publication of international consensus conferences and guidelines, which have been widely available for years. The aim of the study was to describe the clinical management and the eradication rates in a region of Southern Europe (Spain). Between 2010 and 2019, we conducted a retrospective analysis of patients with infection attended by gastroenterologists in two defined areas of the National Health System in Aragón. We compared the appropriateness of therapies according to guidelines, and described the effectiveness of each treatment. A total of 1644 penicillin non-allergic patients were included. The most prescribed therapy between 2010 and 2013 was the 'classic' triple therapy PCA (80%), whereas the 'concomitant' therapy PCAM was chosen by 90% of the gastroenterologists in 2015. After 2016, the use of the quadruple bismuth-containing therapy in a single capsule (Pylera) quickly increased, representing almost half of the overall prescriptions in 2019. Throughout the decade, adherence to guidelines was 76.4% and global efficacy was 70.7% (ITT). Triple therapies' eradication rates were lower than 70% (ITT), whereas eradication rates with quadruple therapies achieved or were over 80% (ITT). In conclusion, despite the use of quadruple therapies and optimized treatments, the effectiveness of management in daily clinical practice is far from the target of 90%.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9171584PMC
http://dx.doi.org/10.3390/antibiotics11050698DOI Listing

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