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Impact of Particle Size and Sintering Temperature on Calcium Phosphate Gyroid Structure Scaffolds for Bone Tissue Engineering.
J Funct Biomater
November 2024
Siegfried Weller Research Institute, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tübingen, BG Trauma Center Tübingen, 72076 Tübingen, Germany.
Due to the chemical composition and structure of the target tissue, autologous bone grafting remains the gold standard for orthopedic applications worldwide. However, ongoing advancements in alternative grafting materials show that 3D-printed synthetic biomaterials offer many advantages. For instance, they provide high availability, have low clinical limitations, and can be designed with a chemical composition and structure comparable to the target tissue.
View Article and Find Full Text PDFDevelopment, and evaluation of film forming solutions for transdermal drug delivery of Zaltoprofen.
J Biomater Sci Polym Ed
December 2024
Department of Pharmaceutics, Dr. Prabhakar B Kore Basic Science Research Center, Off-campus, KLE College of Pharmacy (A constituent unit of KAHER-Belagavi), Bengaluru, Karnataka, India.
Zaltoprofen (ZAL) is a non-steroidal anti-inflammatory drug (NSAID) with a short half-life (∼2.8 h) due to extensive first pass metabolism. In this context, 16 different polymeric film forming solutions (PFFS) of ZAL were developed using different grades of Eudragits, Polyvinylpyrrolidones, Kollicoat MAE 100 P and Hydroxypropyl cellulose as film formers, and polyethylene glycol 400 as a plasticizer in equal parts of ethanol and isopropyl alcohol used as solvents.
View Article and Find Full Text PDFEdge Chipping Resistance and Flexural Strength of CAD-CAM Ceramics Before and After Thermomechanical Aging.
J Esthet Restor Dent
December 2024
Department of Prosthodontics and Research Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.
Objectives: To evaluate the complementary mechanical properties of dental ceramics using edge chipping resistance (Rea) and flexural strength before and after thermomechanical aging.
Material And Methods: Computer-aided design and computer-aided manufacturing of ceramic materials, including zirconia (ZR), lithium disilicate (LS2), and resin nanoceramics (RNC), were evaluated. Specimens for flexural strength testing were fabricated with dimensions of 3 × 4 × 25 mm, with 30 specimens per group.
Amorphous Solid Dispersions of Glycyrrhetinic Acid: Using Soluplus, PVP, and PVPVA as the Polymer Matrix to Enhance Solubility, Bioavailability, and Stability.
AAPS PharmSciTech
December 2024
Hebei Province Key Laboratory of Research and Development for Chinese Medicine, Chengde Medical University, Chengde, 067000, Hebei, China.
Glycyrrhetinic acid (GA) possesses various pharmacological effects, including anti-inflammatory, anti-tumor, and anti-viral properties. However, its clinical application is limited by poor solubility and low oral bioavailability. Polymers play a crucial role in pharmaceutical formulations, particularly as matrices in excipients to enhance the solubility, bioavailability, and stability of active pharmaceutical ingredients.
View Article and Find Full Text PDFPlatinum-Acetylide Complexes as Nonfullerene Acceptors in Organic Photovoltaic Systems.
Inorg Chem
December 2024
Department of Energy and Materials, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502 Japan.
Three distinct n-type semiconductors were derived from a platinum-trialkyl phosphine complex; to lower their LUMO levels, various indene derivatives were incorporated using thiophene (PtTIC ()), thieno[3,2-]thiophene (PtT2IC ()), and 4-cyclopenta[2,1-:3,4-']dithiophene (PtCDTIC ()) as the acetylide donor units. Single-crystal X-ray diffractometry analysis revealed translinear platinum-acetylide complexation in all cases. The strong (═O···S) interactions between the oxygen atoms of the indene acceptor units and the sulfur atoms of the thiophene-derived donor units induced a highly planar orientation among the heterocyclic ligands, featuring π-π interactions between the planes.
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