Stability studies are essential to be able to assign an expiration date to medications. Color variation is one of the organoleptic characteristics of actives substances or medications which can indicate the presence of contaminations, impurities or degradations products. However there is no data available comparing the often used visual examination with spectrophotometric measurements during stability studies. The aim of this study was therefore to evaluate precisely how different the two methods are, by comparing the change of color of two drug formulations chosen as models, assessed by visual examination versus a spectrophotometric colorimetric analysis. Paracetamol and parenteral nutrition solutions were stored in stress conditions for up to 46 days, and were subjected to a visual examination using color reference solutions and to lightness and chromaticity measurement to determine their specific color by UV-Vis spectrophotometry. The color of paracetamol solutions changed faster when exposed to stress condition (light), as did the PNS when exposed to heat. In both cases, color variations were detected earlier and more precisely by UV-Vis spectrophotometry than by visual examination. Color measurement using an UV-Vis spectrophotometry should advantageously replace visual examination when assessing colors changes during drug stability studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9142492 | PMC |
| http://dx.doi.org/10.1038/s41598-022-13025-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Removal of an incarcerated intrauterine device reaching the serosal surface of the uterus by hysteroscopy alone: a case report.
Front Med (Lausanne)
January 2025
Department of Gynecology and Obstetrics, International Peace Maternity and Child Health Hospital Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai Municipal Key Clinical Specialty, Shanghai, China.
Background: An intrauterine device (IUD) is a widely used long-term contraceptive device for family planning. However, the IUD can lead to various complications. Severe complications and remedial measures caused by IUDs have been reported in the literature; however, detailed surgical approaches for safely removing the IUD within the minimum surgical range have rarely been described especially in postmenopausal women.
View Article and Find Full Text PDFAsperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis.
Front Med (Lausanne)
January 2025
Department of Ophthalmology, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Introduction: Uveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from , is known for its notable anti-inflammatory and antioxidant characteristics.
Methods: The present study explored the potential anti-inflammatory effects and the fundamental processes of ASPA by injecting it or a placebo into the vitreous of rats with endotoxin-induced uveitis (EIU).
Mixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net.
J Bone Oncol
February 2025
School of Mathematics and Computer Science, Quanzhou Normal University, Quanzhou, 362001, China.
Objective: Segmenting and reconstructing 3D models of bone tumors from 2D image data is of great significance for assisting disease diagnosis and treatment. However, due to the low distinguishability of tumors and surrounding tissues in images, existing methods lack accuracy and stability. This study proposes a U-Net model based on double dimensionality reduction and channel attention gating mechanism, namely the DCU-Net model for oncological image segmentation.
View Article and Find Full Text PDFUsing multimodal ultrasound technology to improve the success rate of liver tumor puncture for lesions with poor visibility on conventional ultrasound imaging.
Quant Imaging Med Surg
January 2025
Department of Ultrasonography, Nanjing Drum Tower Hospital, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, China.
Background: The ability of conventional ultrasound (US)-guided liver biopsy to visualize certain liver lesions, particularly those affected by conditions like hepatitis or cirrhosis, which can obscure lesion boundaries and lead to inaccurate biopsy targeting, is limited. This study aimed to evaluate the potential of multimodal US techniques to improve the visibility of liver lesions that are indistinct under conventional US, and to enhance the success rate of percutaneous biopsies.
Methods: In total, 144 patients with liver masses and lesions that were not clearly visible on conventional US from October 2018 to January 2024 were enrolled in this retrospective analysis.
Effectiveness of ultrasound-guided intra-articular drug injections in treating sternoclavicular arthritis: a single-group observational study.
Quant Imaging Med Surg
January 2025
Department of Ultrasound, Yiwu City Dermatology Hospital, Yiwu, China.
Background: Current treatments for non-suppurative sternoclavicular arthritis mainly include conservative therapy and surgery. For patients who are unresponsive to conservative treatment and unwilling to undergo surgery, ultrasound-guided intra-articular drug injections offer a minimally invasive alternative. Due to the lack of efficacy evaluation for this therapy, this study aims to objectively assess the effectiveness and safety of this treatment method.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!